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PMID: 2434921 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

D600 blocks the Ca2+ channel from the outer surface of smooth muscle cell membrane of the rabbit intestine and portal vein.

Pflugers Archiv : European journal of physiology ·Vol. 408 ·No. 1 ·1987-01-00 ·Pages 80-2

Ohya Y, Terada K, Kitamura K, Kuriyama H

Abstract

The voltage dependent Ca2+ inward current in single smooth muscle cells dispersed from the longitudinal muscle layer of the rabbit ileum and rabbit portal vein was recorded using the whole-cell voltage clamp technique. D600 added to the bathing solution inhibited the Ca2+ current, while the intracellular perfusion of this agent did not reduce the amplitude of this current. Thus, D600 probably acts from the outer surface of the membrane. The nature of the Ca2+ channel in smooth muscle cells seems to differ from that in cardiac muscle cells.

MeSH Terms

Animals Calcium/metabolism Cell Membrane/drug effects,metabolism Gallopamil/pharmacology Ileum/drug effects,metabolism In Vitro Techniques Ion Channels/drug effects,metabolism Muscle, Smooth/drug effects,metabolism Muscle, Smooth, Vascular/drug effects,metabolism Portal Vein/drug effects,metabolism Rabbits

Chemicals

Ion Channels Gallopamil Calcium

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Ohya Y

Terada K

Kitamura K

Kuriyama H

References (13)

13 references, click to expand

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Article Info

Journal

Pflugers Archiv : European journal of physiology

Abbr.

Pflugers Arch

ISSN

0031-6768

DOI

10.1007/BF00581844

Published

1987-01-00

Pages

80-2

Language

English

Region

Germany

NLM ID

0154720

Subset

External Links

PubMed source DOI: 10.1007/BF00581844 View journal details

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D600 blocks the Ca2+ channel from the outer surface of smooth muscle cell membrane of the rabbit intestine and portal vein.

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