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PMID: 2439707 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Fine mapping of an immunodominant domain in the transmembrane glycoprotein of human immunodeficiency virus.

Journal of virology ·Vol. 61 ·No. 8 ·1987-08-00 ·Pages 2639-41

Gnann JW, Nelson JA, Oldstone MB

Abstract

Sera from virtually all individuals infected with human immunodeficiency virus contain antibodies against the viral envelope glycoproteins. By using a series of synthetic peptide antigens, we identified an immunodominant domain at amino acid position 598-609 of gp41. The minimal essential epitope is a 7-amino-acid sequence (amino acids 603-609) containing two cysteine residues. Both cysteine residues are required for the antigenic conformation of the sequence, possibly due to creation of a cyclic structure via disulfide bond formation.

MeSH Terms
Acquired Immunodeficiency Syndrome/immunology Amino Acid Sequence Antibodies, Viral/analysis Antigens, Viral/immunology Epitopes Glycoproteins/immunology HIV/immunology Humans Membrane Proteins/immunology Peptide Fragments/chemical synthesis,immunology Structure-Activity Relationship Viral Proteins/immunology
Chemicals
Antibodies, Viral Antigens, Viral Epitopes Glycoproteins Membrane Proteins Peptide Fragments Viral Proteins
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Gnann J W
Nelson J A
Oldstone M B
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21 references, click to expand
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.61.8.2639-2641.1987
Published
1987-08-00
Pages
2639-41
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC255715
Subset
IM
Grants
NIAID NIH HHS · AI 07007 · United States
NINDS NIH HHS · NS 12428 · United States
NINDS NIH HHS · T32NS07078 · United States
External Links
PubMed source DOI: 10.1128/JVI.61.8.2639-2641.1987 PMC Full Text View journal details
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