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PMID: 24403164 Published · ppublish English Comparative Study Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Comparison of sleep spindles and theta oscillations in the hippocampus.

The Journal of neuroscience : the official journal of the Society for Neuroscience ·Vol. 34 ·No. 2 ·2014-01-08 ·Pages 662-74

Sullivan D, Mizuseki K, Sorgi A, Buzsáki G

Abstract

Several network patterns allow for information exchange between the neocortex and the entorhinal-hippocampal complex, including theta oscillations and sleep spindles. How neurons are organized in these respective patterns is not well understood. We examined the cellular-synaptic generation of sleep spindles and theta oscillations in the waking rat and during rapid eye movement (REM) sleep by simultaneously recording local field and spikes in the regions and layers of the hippocampus and entorhinal cortex (EC). We show the following: (1) current source density analysis reveals that similar anatomical substrates underlie spindles and theta in the hippocampus, although the hippocampal subregions are more synchronized during spindles than theta; (2) the spiking of putative principal cells and interneurons in the CA1, CA3, and dentate gyrus subregions of the hippocampus, as well as layers 2, 3, and 5 of medial EC, are significantly phase locked to spindles detected in CA1; (3) the relationship between local field potential (LFP) phase and unit spiking differs between spindles and theta; (4) individual hippocampal principal cells generally do not fire in a rhythmic manner during spindles; (5) power in gamma (30-90 Hz) and epsilon (>90 Hz) bands of hippocampal LFP is modulated by the phase of spindle oscillations; and (6) unit firing rates during spindles were not significantly affected by whether spindles occurred during non-REM or transitions between non-REM and REM sleep. Thus, despite the similar current generator inputs and macroscopic appearance of the LFP, the organization of neuronal firing patterns during spindles bears little resemblance to that of theta oscillations.

Keywords
entorhinal cortex gamma hippocampus sleep spindle theta
MeSH Terms
Animals Hippocampus/physiology Male Rats Rats, Long-Evans Rats, Sprague-Dawley Sleep, REM/physiology Theta Rhythm/physiology
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Sullivan David
Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, Newark, New Jersey 07102, and Neuroscience Institute, School of Medicine, New York University, New York, New York 10016.
Mizuseki Kenji
Sorgi Anthony
Buzsáki György
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Article Info
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
Abbr.
J Neurosci
ISSN
1529-2401
DOI
10.1523/JNEUROSCI.0552-13.2014
Published
2014-01-08
Pages
662-74
Language
English
Region
United States
NLM ID
8102140
PMCID
PMC3870943
Subset
IM
Grants
NIMH NIH HHS · R01 MH054671 · United States
NINDS NIH HHS · R01 NS034994 · United States
NIMH NIH HHS · MH54671 · United States
NINDS NIH HHS · NS034994 · United States
External Links
PubMed source DOI: 10.1523/JNEUROSCI.0552-13.2014 PMC Full Text View journal details
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