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PMID: 24445516 Published · ppublish English Journal Article Review

Mitigating the toxic effects of anticancer immunotherapy.

Nature reviews. Clinical oncology ·Vol. 11 ·No. 2 ·2014-02-00 ·Pages 91-9

Gangadhar TC, Vonderheide RH

Abstract

Advances in our understanding of the regulatory mechanisms of the immune system have led to the development of novel approaches for cancer therapy, including inhibition of immune checkpoints with anti-CTLA-4 and anti-PD-1 antibodies. An increasing number of immunomodulatory treatments are under investigation, and are beginning to show promise in clinical trials. As more-effective therapies become available based on modulation of the immune system in order to trigger or enhance antitumour immune responses, clinicians will need to become familiar with recognizing and controlling the adverse effects arising from immune therapy. This Review describes the toxicity profiles for various anticancer therapies based on the use of agents that block immune checkpoints, immunostimulatory agents, and adoptive T-cell therapy (that is, infusion of modified autologous T cells). The management of patients receiving these treatments presents unique challenges for clinicians. Nevertheless, many of the adverse effects associated with these treatments are reversible and can be managed with supportive care either with or without cessation of therapy. This final point is extremely important given the continued development of new cancer immunotherapies, and the importance of safe and effective use of existing effective FDA-approved agents.

MeSH Terms
Antibodies, Monoclonal/therapeutic use Cancer Vaccines/therapeutic use Drug-Related Side Effects and Adverse Reactions/immunology,prevention & control Humans Immunomodulation Immunotherapy Neoplasms/complications,drug therapy,immunology
Chemicals
Antibodies, Monoclonal Cancer Vaccines
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Gangadhar Tara C
Abramson Cancer Centre, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Vonderheide Robert H
Abramson Cancer Centre, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
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Article Info
Journal
Nature reviews. Clinical oncology
Abbr.
Nat Rev Clin Oncol
ISSN
1759-4782
Published
2014-02-00
Epub
2014-00-21
Pages
91-9
Language
English
Region
England
NLM ID
101500077
Subset
IM
Grants
NCI NIH HHS · R01 CA158186 · United States
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