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PMID: 2445076 Published · ppublish English Comparative Study Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Canine kidney transplantation with FK-506 alone or in combination with cyclosporine and steroids.

Transplantation proceedings ·Vol. 19 ·No. 5 Suppl 6 ·1987-10-00 ·Pages 57-61

Todo S, Demetris AJ, Ueda Y, Imventarza O, Okuda K, Casavilla A, Cemaj S, Ghalab A, Mazzaferro V, Rhoe BS

Abstract

The immunosuppressive agent FK permitted increased kidney transplant survival in dogs over a wide dose range, but with weight loss and manifold evidence of toxicity. The best use of FK at low doses was in combination with CyA and Pred.

MeSH Terms
Animals Body Weight/drug effects Cyclosporins/administration & dosage,therapeutic use Dogs Drug Evaluation, Preclinical Drug Synergism Drug Therapy, Combination Graft Rejection/drug effects Immunosuppressive Agents/administration & dosage,therapeutic use,toxicity Kidney Transplantation Prednisolone/administration & dosage,therapeutic use Pyridines/administration & dosage,therapeutic use,toxicity Tacrolimus Vomiting/chemically induced
Chemicals
Cyclosporins Immunosuppressive Agents Pyridines Prednisolone Tacrolimus
Authors & Affiliations
10 authors, click to expand affiliations / ORCID
Todo S
Department of Surgery, University Health Center of Pittsburgh, PA.
Demetris A J
Ueda Y
Imventarza O
Okuda K
Casavilla A
Cemaj S
Ghalab A
Mazzaferro V
Rhoe B S
References (2)
2 references, click to expand
  1. Effect of a new immunosuppressive agent, FK 506, on heterotopic cardiac allotransplantation in the rat.
    Transplant Proc. 1987 Feb;19(1 Pt 2):1284-6 PMID: 2484094
  2. IMMUNOSUPPRESSION WITH FR 900506 FOR CANINE KIDNEY AND LIVER TRANSPLANTATION.
    Surg Res Commun. 1987 Jan 1;1:333-340 PMID: 21552393
Article Info
Journal
Transplantation proceedings
Abbr.
Transplant Proc
ISSN
0041-1345
Published
1987-10-00
Pages
57-61
Language
English
Region
United States
NLM ID
0243532
PMCID
PMC2903874
Subset
IM
Grants
NIDDK NIH HHS · R01 DK029961-19 · United States
NIADDK NIH HHS · AM-29961 · United States
External Links
PubMed source PMC Full Text View journal details
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