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PMID: 2446645 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Heterogeneous epithelial expression of class II (HLA-DR) determinants and secretory component related to dysplasia in ulcerative colitis.

British journal of cancer ·Vol. 56 ·No. 4 ·1987-10-00 ·Pages 419-24

Rognum TO, Brandtzaeg P, Elgjo K, Fausa O

Abstract

The intensity and degree of heterogeneous epithelial marker expression were evaluated immunohistochemically in 29 mucosal biopsy specimens from 7 ulcerative colitis (UC) patients with dysplasia. Biopsy specimens from UC patients with mild (n = 7) or severe (n = 6) inflammation and from histologically normal samples (n = 7) served as controls. HLA-DR showed heterogeneous epithelial expression in all lesions with high grade dysplasia and in 6 of 8 with low grade dysplasia. SC was heterogeneous stained in 17 of 21 lesions with high grade dysplasia and in all but two lesions with low grade dysplasia. In histologically normal mucosa, SC was homogeneously expressed and epithelial DR was virtually absent. In mildly inflamed UC lesions, SC exhibited patchy distribution in only one sample and DR in two, whereas both SC and DR showed a slight degree of heterogeneous expression in all lesions with severe inflammation. Moreover, the overall intensity of SC staining tended to decrease with increasing degree of inflammation, whereas the opposite was seen for DR. Decreased SC and increased DR expression thus seemed to be related to intensified inflammatory activity, whereas heterogeneous expression of these markers was significantly more related to dysplasia.

MeSH Terms
Adolescent Adult Colitis, Ulcerative/immunology,pathology Colon/immunology,pathology Epitopes/analysis Female Fluorescent Antibody Technique HLA-D Antigens/immunology HLA-DR Antigens/immunology Humans Immunoglobulin Fragments/analysis Intestinal Mucosa/immunology Male Middle Aged Secretory Component/analysis
Chemicals
Epitopes HLA-D Antigens HLA-DR Antigens Immunoglobulin Fragments Secretory Component
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Rognum T O
Institute of Forensic Medicine, Oslo, Norway.
Brandtzaeg P
Elgjo K
Fausa O
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Article Info
Journal
British journal of cancer
Abbr.
Br J Cancer
ISSN
0007-0920
DOI
10.1038/bjc.1987.217
Published
1987-10-00
Pages
419-24
Language
English
Region
England
NLM ID
0370635
PMCID
PMC2001837
Subset
IM
External Links
PubMed source DOI: 10.1038/bjc.1987.217 PMC Full Text View journal details
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