Abstract
The colony-stimulating factors regulate growth, differentiation, and function of blood cells. The effect of granulocyte colony-stimulating factor (G-CSF) on myeloid leukemias is unique among colony-stimulating factors in driving the leukemic cells from a self-renewing malignant state to a mature differentiated phenotype with the concomitant loss of tumorigenicity. This property of G-CSF has led to suggestions that its absence is responsible for lack of differentiation of leukemic cells and that the therapeutic administration of G-CSF could reverse this defect and result in a cure for leukemia. Here we show that the gene coding for human G-CSF is localized to chromosome 17, bands q11.2-21. The translocation of the long arm of chromosome 17 at q12-21 to chromosome 15 is a specific abnormality occurring in a high proportion of, if not all, patients with acute promyelocytic leukemia, a disease characterized by undifferentiated myeloid cells and a dismal prognosis. Abnormalities of the regulation of a specific differentiation factor gene mediated by a specific chromosomal rearrangement may be directly implicated in the pathogenesis of human leukemia.
MeSH Terms
Chromosome Mapping
Chromosomes, Human, Pair 17
Colony-Stimulating Factors/genetics
Granulocyte Colony-Stimulating Factor
Granulocytes
Humans
Karyotyping
Leukemia, Myeloid, Acute/genetics
Nucleic Acid Hybridization
Translocation, Genetic
Chemicals
Colony-Stimulating Factors
Granulocyte Colony-Stimulating Factor
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Simmers R N
Cytogenetics Unit, Adelaide Children's Hospital, Australia.
Smith J
Shannon M F
Wong G
Lopez A F
Baker E
Sutherland G R
Vadas M A
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