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PMID: 2450163 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

A physical map of the human regulator of complement activation gene cluster linking the complement genes CR1, CR2, DAF, and C4BP.

The Journal of experimental medicine ·Vol. 167 ·No. 2 ·1988-02-01 ·Pages 664-9

Rey-Campos J, Rubinstein P, Rodriguez de Cordoba S

Abstract

We report the organization of the human genes encoding the complement components C4-binding protein (C4BP), C3b/C4b receptor (CR1), decay accelerating factor (DAF), and C3dg receptor (CR2) within the regulator of complement activation (RCA) gene cluster. Using pulsed field gel electrophoresis analysis these genes have been physically linked and aligned as CR1-CR2-DAF-C4BP in an 800-kb DNA segment. The very tight linkage between the CR1 and the C4BP loci, contrasted with the relative long DNA distance between these genes, suggests the existence of mechanisms interfering with recombination within the RCA gene cluster.

MeSH Terms
CD55 Antigens Chromosome Mapping Complement Activation Complement C4/genetics,isolation & purification Complement C4b Electrophoresis, Agar Gel Genetic Linkage Humans Membrane Proteins/genetics,isolation & purification Multigene Family Nucleic Acid Hybridization Receptors, Complement/genetics,isolation & purification Receptors, Complement 3b Receptors, Complement 3d
Chemicals
CD55 Antigens Complement C4 Membrane Proteins Receptors, Complement Receptors, Complement 3b Receptors, Complement 3d factor H receptors Complement C4b
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Rey-Campos J
Department of Immunogenetics, New York Blood Center 10021.
Rubinstein P
Rodriguez de Cordoba S
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19 references, click to expand
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.167.2.664
Published
1988-02-01
Pages
664-9
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2188826
Subset
IM
Grants
NIDDK NIH HHS · DK-19631-11 · United States
External Links
PubMed source DOI: 10.1084/jem.167.2.664 PMC Full Text View journal details
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