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PMID: 2450776 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Preferential cytotoxicity on tumor cells by caffeic acid phenethyl ester isolated from propolis.

Experientia ·Vol. 44 ·No. 3 ·1988-03-15 ·Pages 230-2

Grunberger D, Banerjee R, Eisinger K, Oltz EM, Efros L, Caldwell M, Estevez V, Nakanishi K

Abstract

The honeybee hive product, propolis, is a folk medicine employed for treating various ailments. Many important pharmaceutical properties have been ascribed to propolis, including anti-inflammatory, antiviral, immunostimulatory and carcinostatic activities. Propolis extracts have provided an active component identified as caffeic acid phenethyl ester (CAPE), which was readily prepared in one step. Differential cytotoxicity has been observed in normal rat/human versus transformed rat/human melanoma and breast carcinoma cell lines in the presence of CAPE.

MeSH Terms
Animals Caffeic Acids/toxicity Cell Division/drug effects Cell Survival/drug effects Cells, Cultured Cinnamates/toxicity Cytotoxins DNA/biosynthesis Ethanol/analogs & derivatives In Vitro Techniques Phenylethyl Alcohol/analogs & derivatives,toxicity Propolis/pharmacology Rats Resins, Plant/pharmacology
Chemicals
Caffeic Acids Cinnamates Cytotoxins Resins, Plant Ethanol DNA Propolis caffeic acid phenethyl ester Phenylethyl Alcohol
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Grunberger D
Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University, New York, New York 10032.
Banerjee R
Eisinger K
Oltz E M
Efros L
Caldwell M
Estevez V
Nakanishi K
References (5)
5 references, click to expand
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    Biochim Biophys Acta. 1984 Jan 17;792(1):92-7 PMID: 6318834
  2. Examination of the chemical composition of propolis I. Isolation and identification of the 3,4-dihydroxycinnamic acid (caffeic acid) from propolis.
    Experientia. 1970;26(7):713 PMID: 5431122
  3. In vitro studies on the cytostatic activity of propolis extracts.
    Arzneimittelforschung. 1980;30(11):1847-8 PMID: 7192990
  4. Growth regulation of human melanocytes: mitogenic factors in extracts of melanoma, astrocytoma, and fibroblast cell lines.
    Science. 1985 Sep 6;229(4717):984-6 PMID: 4023718
  5. Analysis of type 5 adenovirus transformation with a cloned rat embryo cell line (CREF).
    Proc Natl Acad Sci U S A. 1982 Jun;79(11):3527-31 PMID: 6954499
Article Info
Journal
Experientia
Abbr.
Experientia
ISSN
0014-4754
DOI
10.1007/BF01941717
Published
1988-03-15
Pages
230-2
Language
English
Region
Switzerland
NLM ID
0376547
Subset
IM
Grants
NIAID NIH HHS · AI 10187 · United States
NCI NIH HHS · CA 21111 · United States
NCI NIH HHS · CA 31696 · United States
External Links
PubMed source DOI: 10.1007/BF01941717
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