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PMID: 24529368 Published · ppublish English

mTORC1: turning off is just as important as turning on.

Cell ·Vol. 156 ·No. 4 ·2014-04-23

Benjamin Don, Hall Michael N

Abstract

mTORC1 is activated primarily on the lysosome. Menon et al. and Demetriades et al. show that mTORC1 deactivation on the lysosome is determined by recruitment of its negative regulator, the tumor suppressor complex TSC1-TSC2. These reports highlight the importance of subcellular localization in the regulation of mTORC1.

Article Info
Journal
Cell
Abbr.
Cell
ISSN
0092-8674
DOI
10.1016/j.cell.2014.01.057
Published
2014-04-23
Indexed
2014-02-17
Updated
2014-02-17
Language
English
Country/Region
United States
NLM ID
0413066
External Links
PubMed source DOI: 10.1016/j.cell.2014.01.057 View journal details
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