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PMID: 2457254 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Antiphosphotyrosine recovery of phospholipase C activity after EGF treatment of A-431 cells.

Science (New York, N.Y.) ·Vol. 241 ·No. 4868 ·1988-08-19 ·Pages 968-70

Wahl MI, Daniel TO, Carpenter G

Abstract

A tenfold increase in phospholipase C activity specific for phosphatidylinositol 4,5-bisphosphate (PIP2) was immunopurified from extracts of A-431 epidermoid carcinoma cells stimulated with epidermal growth factor. This finding suggests a biochemical link between growth factor-stimulated tyrosine kinase activity and PIP2 hydrolysis.

MeSH Terms
Antibodies/immunology Carcinoma, Squamous Cell Chromatography, High Pressure Liquid Cytosol/enzymology Epidermal Growth Factor/pharmacology Hydrolysis Inositol Phosphates/metabolism Phosphatidylinositol 4,5-Diphosphate Phosphatidylinositols/metabolism Phosphorylation Phosphotyrosine Protein-Tyrosine Kinases/metabolism Substrate Specificity Tumor Cells, Cultured Type C Phospholipases/metabolism Tyrosine/analogs & derivatives,immunology,metabolism
Chemicals
Antibodies Inositol Phosphates Phosphatidylinositol 4,5-Diphosphate Phosphatidylinositols Phosphotyrosine Tyrosine Epidermal Growth Factor Protein-Tyrosine Kinases Type C Phospholipases
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Wahl M I
Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232.
Daniel T O
Carpenter G
Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
0036-8075
DOI
10.1126/science.2457254
Published
1988-08-19
Pages
968-70
Language
English
Region
United States
NLM ID
0404511
Subset
IM
Grants
NCI NIH HHS · CA 43720 · United States
NIDDK NIH HHS · DK 38517 · United States
NIGMS NIH HHS · GM 07347 · United States
External Links
PubMed source DOI: 10.1126/science.2457254 View journal details
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