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PMID: 24587730 Published · epublish English Controlled Clinical Trial Journal Article Research Support, Non-U.S. Gov't

Sperm cryopreservation before testicular cancer treatment and its subsequent utilization for the treatment of infertility.

TheScientificWorldJournal ·Vol. 2014 ·2014-00-00 ·Pages 575978

Záková J, Lousová E, Ventruba P, Crha I, Pochopová H, Vinklárková J, Tesařová E, Nussir M

Abstract

In this study we report our results with storage of cryopreserved semen intended for preservation and subsequent infertility treatment in men with testicular cancer during the last 18 years. Cryopreserved semen of 523 men with testicular cancer was collected between October 1995 and the end of December 2012. Semen of 34 men (6.5%) was used for fertilization of their partners. They underwent 57 treatment cycles with cryopreserved, fresh, and/or donor sperm. A total of 557 men have decided to freeze their semen before cancer treatment. Azoospermia was diagnosed in 34 men (6.1%), and semen was cryopreserved in 532 patients. Seminoma was diagnosed in 283 men (54.1%) and nonseminomatous germ cell tumors in 240 men (45.9%). 34 patients who returned for infertility treatment underwent 46 treatment cycles with cryopreserved sperm. Totally 16 pregnancies were achieved, that is, 34.8% pregnancy rate. The testicular cancer survivors have a good chance of fathering a child by using sperm cryopreserved prior to the oncology treatment, even when it contains only limited number of spermatozoa.

MeSH Terms
Adult Cryopreservation/methods Female Fertilization in Vitro/methods Humans Infertility, Male/etiology,rehabilitation,therapy Male Seminoma/complications,rehabilitation Spermatozoa/physiology Testicular Neoplasms/complications,rehabilitation
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Záková Jana
Department of Gynaecology and Obstetrics, Faculty of Medicine, Masaryk University and Faculty Hospital Brno, Obilní trh 11, 602 00 Brno, Czech Republic.
Lousová Eva
Department of Gynaecology and Obstetrics, Faculty of Medicine, Masaryk University and Faculty Hospital Brno, Obilní trh 11, 602 00 Brno, Czech Republic.
Ventruba Pavel
Department of Gynaecology and Obstetrics, Faculty of Medicine, Masaryk University and Faculty Hospital Brno, Obilní trh 11, 602 00 Brno, Czech Republic.
Crha Igor
Department of Gynaecology and Obstetrics, Faculty of Medicine, Masaryk University and Faculty Hospital Brno, Obilní trh 11, 602 00 Brno, Czech Republic.
Pochopová Hana
Department of Gynaecology and Obstetrics, Faculty of Medicine, Masaryk University and Faculty Hospital Brno, Obilní trh 11, 602 00 Brno, Czech Republic.
Vinklárková Jaroslava
Transfusion and Tissue Department, Faculty Hospital Brno, Jihlavská 20, 625 00 Brno, Czech Republic.
Tesařová Eva
Transfusion and Tissue Department, Faculty Hospital Brno, Jihlavská 20, 625 00 Brno, Czech Republic.
Nussir Mohamed
Department of Urology, Faculty of Medicine, Masaryk University and Faculty Hospital Brno, Jihlavská 20, 625 00 Brno, Czech Republic.
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Article Info
Journal
TheScientificWorldJournal
Abbr.
ScientificWorldJournal
ISSN
1537-744X
DOI
10.1155/2014/575978
Published
2014-00-00
Epub
2014-00-22
Pages
575978
Language
English
Region
United States
NLM ID
101131163
PMCID
PMC3919096
Subset
IM
External Links
PubMed source DOI: 10.1155/2014/575978 PMC Full Text View journal details
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