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PMID: 24622616 Published · ppublish English Journal Article Comment

A new protein kinase cascade.

Nature reviews. Molecular cell biology ·Vol. 15 ·No. 4 ·2014-04-00 ·Pages 223

Hardie DG

Abstract

暂无摘要

MeSH Terms
Acetyl-CoA Carboxylase/metabolism Adaptor Proteins, Signal Transducing/metabolism Adaptor Proteins, Vesicular Transport/metabolism Animals Apoptosis/physiology Carrier Proteins Cholesterol/biosynthesis Fatty Acids/biosynthesis Humans Hydroxymethylglutaryl CoA Reductases/metabolism Ligases/metabolism Microsomes, Liver/enzymology Multienzyme Complexes/metabolism Protein Kinases/metabolism Protein Serine-Threonine Kinases/metabolism Proteins
Chemicals
Adaptor Proteins, Signal Transducing Adaptor Proteins, Vesicular Transport Carrier Proteins Fatty Acids Multienzyme Complexes Proteins Cholesterol Hydroxymethylglutaryl CoA Reductases Protein Kinases Protein Serine-Threonine Kinases Ligases Acetyl-CoA Carboxylase
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Hardie D Grahame
Division of Cell Signalling and Immunology, College of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, UK.
References (5)
5 references, click to expand
  1. Reversible modulation of the activities of both liver microsomal hydroxymethylglutaryl coenzyme A reductase and its inactivating enzyme. Evidence for regulation by phosphorylation-dephosphorylation.
    Biochem Biophys Res Commun. 1978 Apr 28;81(4):1268-77 PMID: 666819
  2. A common bicyclic protein kinase cascade inactivates the regulatory enzymes of fatty acid and cholesterol biosynthesis.
    FEBS Lett. 1987 Nov 2;223(2):217-22 PMID: 2889619
  3. Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade.
    J Biol. 2003;2(4):28 PMID: 14511394
  4. LKB1 is the upstream kinase in the AMP-activated protein kinase cascade.
    Curr Biol. 2003 Nov 11;13(22):2004-8 PMID: 14614828
  5. The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress.
    Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3329-35 PMID: 14985505
Article Info
Journal
Nature reviews. Molecular cell biology
Abbr.
Nat Rev Mol Cell Biol
ISSN
1471-0080
DOI
10.1038/nrm3771
Published
2014-04-00
Epub
2014-00-12
Pages
223
Language
English
Region
England
NLM ID
100962782
Subset
IM
Grants
Wellcome Trust · 097726 · United Kingdom
Corrections
CommentOn
PMID: 666819
CommentOn
PMID: 2889619
CommentOn
PMID: 14511394
CommentOn
PMID: 14614828
CommentOn
PMID: 14985505
External Links
PubMed source DOI: 10.1038/nrm3771 View journal details
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