Argyrophilic proteins of the nucleolar organizer region in bladder-tumours.

Virchows Archiv. A, Pathological anatomy and histopathology ·Vol. 414 ·No. 4 ·1989-00-00 ·Pages 365-9

Ooms EC, Veldhuizen RW

Abstract

The introduction of a simple one-stage silver nitrate stain as a method of displaying nucleolar organizer regions (NOR's) in formalin-fixed tissue has made it possible to examine the significance of these structures in tumour pathology. In the current study argyrophilic proteins of the NOR's were studied in 39 consecutive patients with bladder tumours. The results indicate that the counting of silver staining particles is only of limited value in grading bladder tumours and that this method is not superior to other additional grading techniques such as histo-morphometry and flow cytometry.

MeSH Terms

Adult Aged Aged, 80 and over Female Humans Male Middle Aged Nucleolus Organizer Region/analysis,ultrastructure Silver Nitrate Silver Proteins/analysis Staining and Labeling/methods Urinary Bladder Neoplasms/analysis,pathology,ultrastructure

Chemicals

Silver Proteins Silver Nitrate

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Ooms E C

Department of Pathology, Westeinde Ziekenhuis, Den Haag, The Netherlands.

Veldhuizen R W

References (11)

11 references, click to expand

Classification of bladder tumours based on the cellular pattern. Preliminary report of a clinical-pathological study of 300 cases with a minimum follow-up of eight years.
Acta Chir Scand. 1965 Oct;130(4):371-8 PMID: 5842510
The reproducibility of a quantitative grading system of bladder tumours.
Histopathology. 1985 May;9(5):501-9 PMID: 4007789
Analysis of the performance of pathologists in the grading of bladder tumors.
Hum Pathol. 1983 Feb;14(2):140-3 PMID: 6832758
Further evidence that phosphoprotein C23 (110 kD/pI 5.1) is the nucleolar silver staining protein.
Exp Cell Res. 1984 May;152(1):260-5 PMID: 6201373
Nucleolar organizer regions in lymphomas.
J Pathol. 1987 Feb;151(2):111-8 PMID: 2437276
Morphometric grading of bladder tumors in comparison with histologic grading by pathologists.
Hum Pathol. 1983 Feb;14(2):144-50 PMID: 6832759
Immunolocalization of the 100 K nucleolar protein in CHO cells.
Biol Cell. 1985;53(2):99-109 PMID: 3159455
The prognostic significance of morphometry in T1 bladder tumours.
Histopathology. 1981 May;5(3):311-8 PMID: 7239451
Immunolocalization of the 100 kDa nucleolar protein during the mitotic cycle in CHO cells.
Biol Cell. 1985;53(3):209-18 PMID: 2410074
Evaluation of nucleolar organizer region-associated proteins in breast malignancy.
Histopathology. 1988 Feb;12(2):113-25 PMID: 2452777
Nucleolar organiser region associated proteins in cutaneous melanotic lesions: a quantitative study.
J Clin Pathol. 1987 Aug;40(8):885-9 PMID: 3654987

Article Info

Journal

Virchows Archiv. A, Pathological anatomy and histopathology

Abbr.

Virchows Arch A Pathol Anat Histopathol

ISSN

0174-7398

DOI

10.1007/BF00734093

Published

1989-00-00

Pages

365-9

Language

English

Region

Germany

NLM ID

8302198

Subset

External Links

PubMed source DOI: 10.1007/BF00734093

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Argyrophilic proteins of the nucleolar organizer region in bladder-tumours.

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