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PMID: 2476401 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Antigenic variation within serotypes of Cryptococcus neoformans detected by monoclonal antibodies specific for the capsular polysaccharide.

Infection and immunity ·Vol. 57 ·No. 10 ·1989-10-00 ·Pages 3240-2

Spiropulu C, Eppard RA, Otteson E, Kozel TR

Abstract

The serotype-specific polysaccharide was isolated from four to seven strains of each of the four major serotypes of Cryptococcus neoformans. Reactivities of polysaccharides with seven monoclonal antibodies raised against polysaccharides of serotypes A, B, C, and D were assessed by an enzyme-linked immunosorbent assay and double immunodiffusion. The results indicated that there is heterogeneity within all four serotypes in the expression of epitopes reactive with monoclonal antibodies.

MeSH Terms
Animals Antibodies, Bacterial Antibodies, Monoclonal Antibody Specificity Antigen-Antibody Reactions Antigenic Variation Antigens, Bacterial/immunology Cryptococcus/immunology Cryptococcus neoformans/classification,immunology Enzyme-Linked Immunosorbent Assay Epitopes/immunology Mice Polysaccharides, Bacterial/immunology Serotyping
Chemicals
Antibodies, Bacterial Antibodies, Monoclonal Antigens, Bacterial Epitopes Polysaccharides, Bacterial
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Spiropulu C
Department of Microbiology, University of Nevada, Reno 89557.
Eppard R A
Otteson E
Kozel T R
References (9)
9 references, click to expand
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    Carbohydr Res. 1980 Jun;82(1):103-11 PMID: 6772300
  2. Structure and antigenic activity of the capsular polysaccharide of Cryptococcus neoformans serotype A.
    Mol Immunol. 1980 Aug;17(8):1025-32 PMID: 6777664
  3. Capsular polysaccharides from a parent strain and from a possible, mutant strain of Cryptococcus neoformans serotype A.
    Carbohydr Res. 1981 Sep 16;95(2):237-48 PMID: 7028261
  4. Improved diagnostic medium for separation of Cryptococcus neoformans var. neoformans (serotypes A and D) and Cryptococcus neoformans var. gattii (serotypes B and C).
    J Clin Microbiol. 1982 Mar;15(3):535-7 PMID: 7042750
  5. Serologic grouping of Cryptococcus neoformans.
    Proc Soc Exp Biol Med. 1968 Mar;127(3):820-3 PMID: 5651140
  6. Chemical characterization of capsular polysaccharide from Cryptococcus neoformans serotype A-D.
    Microbiol Immunol. 1985;29(10):981-91 PMID: 3908888
  7. Production and characterization of monoclonal antibodies specific for Cryptococcus neoformans capsular polysaccharide.
    Infect Immun. 1987 Aug;55(8):1895-9 PMID: 2440810
  8. Structure determination of Cryptococcus neoformans serotype A-variant glucuronoxylomannan by 13C-n.m.r. spectroscopy.
    Carbohydr Res. 1988 Jan 15;172(1):113-38 PMID: 3280130
  9. Antigenic characterization of Cryptococcus neoformans serotypes and its application to serotyping of clinical isolates.
    J Clin Microbiol. 1982 Jul;16(1):22-9 PMID: 6179964
Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.57.10.3240-3242.1989
Published
1989-10-00
Pages
3240-2
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC260798
Subset
IM
Grants
NIAID NIH HHS · AI14209 · United States
NIAID NIH HHS · AI24357 · United States
External Links
PubMed source DOI: 10.1128/iai.57.10.3240-3242.1989 PMC Full Text View journal details
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