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PMID: 2478657 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

The neutrophil-activating peptide NAF/NAP-1 induces histamine and leukotriene release by interleukin 3-primed basophils.

The Journal of experimental medicine ·Vol. 170 ·No. 5 ·1989-11-01 ·Pages 1787-92

Dahinden CA, Kurimoto Y, De Weck AL, Lindley I, Dewald B, Baggiolini M

Abstract

IgE-independent mediator release from basophils is considered an important event in inflammation, particularly in nonallergic immediate hypersensitivity and in allergic late-phase reactions. This study demonstrates that after exposure to IL-3, basophils release histamine and leukotrienes in response to the neutrophil-activating peptide NAF/NAP-1. Thus, the sequential action of two pure cytokines can promote basophils mediator release. In the presence of IL-3, NAF/NAP-1 functions like a "histamine-releasing factor" and may therefore not only induce cellular infiltration but also provoke symptoms of hypersensitivity reactions.

MeSH Terms
Basophils/physiology Dose-Response Relationship, Drug Glucuronidase/metabolism Histamine Release/drug effects Humans Immunoglobulin E/physiology In Vitro Techniques Interleukin-3/pharmacology Interleukin-8 Neutrophils/physiology Peptides/pharmacology SRS-A/metabolism
Chemicals
Interleukin-3 Interleukin-8 Peptides SRS-A Immunoglobulin E Glucuronidase
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Dahinden C A
Institute of Clinical Immunology, University of Bern, Switzerland.
Kurimoto Y
De Weck A L
Lindley I
Dewald B
Baggiolini M
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16 references, click to expand
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.170.5.1787
Published
1989-11-01
Pages
1787-92
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2189502
Subset
IM
External Links
PubMed source DOI: 10.1084/jem.170.5.1787 PMC Full Text View journal details
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