Glycine modulation of the NMDA receptor/channel complex.

Trends in neurosciences ·Vol. 12 ·No. 9 ·1989-09-00 ·Pages 349-53

Thomson AM

Abstract

One class of excitatory amino acid (EAA) receptor, the N-methyl-D-aspartate (NMDA) receptor, has excited enormous interest because of its unique pharmacological and physiological properties. Yet another property of this receptor/channel complex has recently emerged: its activation is greatly enhanced by and may even be dependent on, sub-micromolar concentrations of glycine.

MeSH Terms

Amino Acids/metabolism Evoked Potentials/drug effects Glycine/antagonists & inhibitors,pharmacology Humans Ion Channels/drug effects,physiology Neurons/physiology Receptors, N-Methyl-D-Aspartate Receptors, Neurotransmitter/drug effects,physiology Synapses/drug effects,physiology

Chemicals

Amino Acids Ion Channels Receptors, N-Methyl-D-Aspartate Receptors, Neurotransmitter Glycine

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Thomson A M

Article Info

Journal

Trends in neurosciences

Abbr.

Trends Neurosci

ISSN

0166-2236

DOI

10.1016/0166-2236(89)90042-8

Published

1989-09-00

Pages

349-53

Language

English

Region

England

NLM ID

7808616

Subset

Grants

Wellcome Trust · United Kingdom

External Links

PubMed source DOI: 10.1016/0166-2236(89)90042-8 View journal details

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Glycine modulation of the NMDA receptor/channel complex.

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