Hypoxic pulmonary hypertension: the paradigm is changing.

Experimental physiology ·Vol. 99 ·No. 6 ·2014-06-00 ·Pages 837-8

Rowan SC, McLoughlin P

Abstract

暂无摘要

MeSH Terms

Animals Calcium Channels, L-Type/biosynthesis Calcium Channels, T-Type/biosynthesis Gene Expression Regulation Hypertension, Pulmonary/physiopathology,prevention & control Hypoxia/metabolism,physiopathology Male Protein Serine-Threonine Kinases/antagonists & inhibitors Pulmonary Artery/metabolism Pulmonary Circulation/physiology Vasoconstriction/drug effects,physiology Vasoconstrictor Agents/pharmacology

Chemicals

Calcium Channels, L-Type Calcium Channels, T-Type Vasoconstrictor Agents Protein Serine-Threonine Kinases

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Rowan S C

UCD School of Medicine and Medical Sciences, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland.

McLoughlin P

UCD School of Medicine and Medical Sciences, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland [email protected].

References (5)

5 references, click to expand

Chronic hypoxia selectively enhances L- and T-type voltage-dependent Ca2+ channel activity in pulmonary artery by upregulating Cav1.2 and Cav3.2.
Am J Physiol Lung Cell Mol Physiol. 2013 Jul 15;305(2):L154-64 PMID: 23686856
The pathophysiological basis of chronic hypoxic pulmonary hypertension in the mouse: vasoconstrictor and structural mechanisms contribute equally.
Exp Physiol. 2012 Jun;97(6):796-806 PMID: 22366565
Attenuation of acute hypoxic pulmonary vasoconstriction and hypoxic pulmonary hypertension in mice by inhibition of Rho-kinase.
Am J Physiol Lung Cell Mol Physiol. 2004 Oct;287(4):L656-64 PMID: 14977625
Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension.
Nature. 1997 Oct 30;389(6654):990-4 PMID: 9353125
Effect of changes in pH on wall tension in isolated rat pulmonary artery: role of the RhoA/Rho-kinase pathway.
Am J Physiol Lung Cell Mol Physiol. 2004 Oct;287(4):L673-84 PMID: 14766667

Article Info

Journal

Experimental physiology

Abbr.

Exp Physiol

ISSN

1469-445X

DOI

10.1113/expphysiol.2014.078485

[email protected]

Published

2014-06-00

Pages

837-8

Language

English

Region

England

NLM ID

9002940

PMCID

PMC4204154

Subset

Corrections

CommentOn

PMID: 14977625

CommentOn

PMID: 22366565

CommentOn

PMID: 23686856

External Links

PubMed source DOI: 10.1113/expphysiol.2014.078485 PMC Full Text View journal details

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Hypoxic pulmonary hypertension: the paradigm is changing.

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