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PMID: 2498647 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Rapid repression of quiescence-specific gene expression by epidermal growth factor, insulin, and pp60v-src.

Molecular and cellular biology ·Vol. 9 ·No. 3 ·1989-03-00 ·Pages 1371-5

Bedard PA, Yannoni Y, Simmons DL, Erikson RL

Abstract

We isolated a cDNA for p20K, a secreted protein preferentially synthesized in nonproliferating cells. p20K mRNA and protein levels declined rapidly following treatment with various mitogens. DNA sequence analysis of the p20K cDNA predicted a novel protein distantly related to alpha 2 mu-globulin and plasma retinol-binding protein.

MeSH Terms
Amino Acid Sequence Animals Avian Proteins Base Sequence Blood Proteins/genetics,metabolism Cells, Cultured DNA/genetics Epidermal Growth Factor/pharmacology Gene Expression Regulation Insulin/pharmacology Interphase Lipocalins Molecular Sequence Data Oncogene Protein pp60(v-src) RNA, Messenger/genetics,metabolism Retroviridae Proteins/pharmacology
Chemicals
Avian Proteins Blood Proteins Insulin Lipocalins RNA, Messenger Retroviridae Proteins Epidermal Growth Factor DNA Oncogene Protein pp60(v-src)
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Bedard P A
Department of Cellular and Developmental Biology, Harvard University, Cambridge, Massachusetts 02138.
Yannoni Y
Simmons D L
Erikson R L
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Article Info
Journal
Molecular and cellular biology
Abbr.
Mol Cell Biol
ISSN
0270-7306
DOI
10.1128/mcb.9.3.1371-1375.1989
Published
1989-03-00
Pages
1371-5
Language
English
Region
United States
NLM ID
8109087
PMCID
PMC362736
Subset
IM
Databases
GENBANK
M25784
External Links
PubMed source DOI: 10.1128/mcb.9.3.1371-1375.1989 PMC Full Text View journal details
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