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PMID: 2499251 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Efficacy of fleroxacin in experimental methicillin-resistant Staphylococcus aureus endocarditis.

Antimicrobial agents and chemotherapy ·Vol. 33 ·No. 4 ·1989-04-00 ·Pages 519-21

Kaatz GW, Seo SM, Barriere SL, Albrecht LM, Rybak MJ

Abstract

The efficacy of fleroxacin versus that of vancomycin was assessed by using the rabbit model of methicillin-resistant Staphylococcus aureus endocarditis. Animals were treated with fleroxacin (30 mg/kg of body weight every 8 h) or vancomycin (17.5 mg/kg every 6 h) for 4 days. These antimicrobial agents were equally effective in clearing bacteremia, reducing bacterial counts in vegetations and tissues, and curing endocarditis. However, resistance to fleroxacin at fivefold the MIC arose in the test strain of S. aureus in 8% of animals that received the drug. We conclude that fleroxacin is as efficacious as vancomycin in this model of a serious systemic S. aureus infection, but modest resistance to fleroxacin may develop during therapy.

MeSH Terms
Animals Ciprofloxacin/analogs & derivatives,pharmacokinetics,pharmacology,therapeutic use Drug Resistance, Microbial Endocarditis, Bacterial/drug therapy,microbiology Fleroxacin Male Methicillin/pharmacology Microbial Sensitivity Tests Penicillin Resistance Rabbits Staphylococcal Infections/drug therapy,microbiology Staphylococcus aureus/drug effects
Chemicals
Ciprofloxacin Fleroxacin Methicillin
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Kaatz G W
Department of Internal Medicine, Wayne State University School of Medicine, Detroit, Michigan.
Seo S M
Barriere S L
Albrecht L M
Rybak M J
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12 references, click to expand
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Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.33.4.519
Published
1989-04-00
Pages
519-21
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC172471
Subset
IM
External Links
PubMed source DOI: 10.1128/AAC.33.4.519 PMC Full Text View journal details
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