Home LiteratureArticle Details
PMID: 2499511 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Developmental genetics of loci at the base of the X chromosome of Drosophila melanogaster.

Genetics ·Vol. 121 ·No. 2 ·1989-02-00 ·Pages 313-31

Perrimon N, Smouse D, Miklos GL

Abstract

We have conducted a genetic and developmental analysis of the 26 contiguous genetic complementation groups within the 19D3-20F2 interval of the base of the X chromosome, a region of 34 polytene bands delimited by the maroon-like and suppressor of forked loci. Within this region there are four loci which cause visible phenotypes but which have little or no effect on zygotic viability (maroon-like, little fly, small optic lobes and sluggish). There are 22 loci which, when mutated, are zygotic lethals and three of these, legless/runt, folded gastrulation and 13E3, have severe effects on embryonic development. In addition, three visible phenotypes have been defined only by overlapping deficiencies (melanized-like, tumorous head, and varied outspread). We have analyzed the lethal phases and maternal requirement of 58 mutations at 22 of the zygotic lethal loci by means of germline clone analysis using the dominant female sterile technique. Additionally, all lethal complementation groups, as well as a specific subset of deficiencies, have been studied histologically for defects in the development of the central and peripheral embryonic nervous systems.

MeSH Terms
Animals Chromosome Mapping Drosophila melanogaster/embryology,genetics Female Gastrula/physiology Genes, Lethal Genetic Complementation Test Germ Cells Nervous System/embryology Phenotype Suppression, Genetic X Chromosome/ultrastructure
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Perrimon N
Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115.
Smouse D
Miklos G L
References (40)
40 references, click to expand
  1. Control of neuronal fate by the Drosophila segmentation gene even-skipped.
    Nature. 1988 May 26;333(6171):376-8 PMID: 3374572
  2. Mutations altering synaptic connectivity between identified neurons in Drosophila.
    J Neurosci. 1984 Feb;4(2):530-8 PMID: 6699687
  3. High proportion of multi-locus deletions among hycanthone-induced X-linked recessive lethals in Drosophila melanogaster.
    Mutat Res. 1983 Feb;107(2):187-201 PMID: 6408464
  4. A rehabilitation of the genetic map of the 84B-D region in Drosophila melanogaster.
    Genetics. 1986 Sep;114(1):111-23 PMID: 3095179
  5. Dosage requirements for runt in the segmentation of Drosophila embryos.
    Cell. 1986 Apr 25;45(2):289-99 PMID: 3084105
  6. Lethality patterns and morphology of selected lethal and semi-lethal mutations in the zeste-white region of Drosophila melanogaster.
    Genetics. 1972 Dec;72(4):615-38 PMID: 4631596
  7. The genetics of the dorsal-Bicaudal-D region of Drosophila melanogaster.
    Genetics. 1986 Jul;113(3):665-78 PMID: 3089869
  8. A Genetic and Cytogenetic Analysis of the Region Surrounding the Lsp-1 beta-Gene in DROSOPHILA MELANOGASTER.
    Genetics. 1985 Jan;109(1):145-56 PMID: 17246246
  9. Mutations affecting segment number and polarity in Drosophila.
    Nature. 1980 Oct 30;287(5785):795-801 PMID: 6776413
  10. Models for positional signalling, the threefold subdivision of segments and the pigmentation pattern of molluscs.
    J Embryol Exp Morphol. 1984 Nov;83 Suppl:289-311 PMID: 6533242
  11. Distribution of MR-induced sex-linked recessive lethal mutations in Drosophila melanogaster.
    Mutat Res. 1985 Jun-Jul;150(1-2):261-75 PMID: 3923338
  12. Genetic instability in Drosophila melanogaster: cytogenetic analysis of MR-induced X-chromosome deficiencies.
    Proc Natl Acad Sci U S A. 1987 Jul;84(13):4533-7 PMID: 3110770
  13. Cell recognition during neuronal development.
    Science. 1984 Sep 21;225(4668):1271-9 PMID: 6474176
  14. Localization of the genes shaking-B, small optic lobes, sluggish-A, stoned and stress-sensitive-C to a well-defined region on the X-chromosome of Drosophila melanogaster.
    J Neurogenet. 1987 Jan;4(1):1-19 PMID: 3104567
  15. The genetics of dopa decarboxylase in Drosophila melanogaster. II. Isolation and characterization of dopa-decarboxylase-deficient mutants and their relationship to the alpha-methyl-dopa-hypersensitive mutants.
    Genetics. 1976 Oct;84(2):287-310 PMID: 826448
  16. Tumorous-head-type mutants of the distal bithorax complex cause dominant gain and recessive loss of function in Drosophila melanogaster.
    Dev Biol. 1988 Jan;125(1):8-18 PMID: 3119403
  17. Antibodies to horseradish peroxidase as specific neuronal markers in Drosophila and in grasshopper embryos.
    Proc Natl Acad Sci U S A. 1982 Apr;79(8):2700-4 PMID: 6806816
  18. Expression and function of the segmentation gene fushi tarazu during Drosophila neurogenesis.
    Science. 1988 Jan 8;239(4836):170-5 PMID: 2892267
  19. The localization of "ordinary" sex-linked genes in section 20 of the polytene X chromosome of Drosophila melanogaster.
    Chromosoma. 1973 Nov 21;44(2):183-202 PMID: 4204880
  20. The localized requirements for a gene affecting segmentation in Drosophila: analysis of larvae mosaic for runt.
    Dev Biol. 1985 Jun;109(2):321-35 PMID: 3996753
  21. An altered electroretinogram transient associated with an unusual jump response in a mutant of Drosophila.
    Cell Mol Neurobiol. 1983 Jun;3(2):143-9 PMID: 6418384
  22. The tko locus, site of a behavioral mutation in D. melanogaster, codes for a protein homologous to prokaryotic ribosomal protein S12.
    Cell. 1987 Oct 23;51(2):165-73 PMID: 3117373
  23. Microcloning reveals a high frequency of repetitive sequences characteristic of chromosome 4 and the beta-heterochromatin of Drosophila melanogaster.
    Proc Natl Acad Sci U S A. 1988 Apr;85(7):2051-5 PMID: 3127823
  24. Molecular and genetic studies on the euchromatin-heterochromatin transition region of the X chromosome of Drosophila melanogaster. 1. A cloned entry point near to the uncoordinated (unc) locus.
    Chromosoma. 1984;89(3):218-27 PMID: 6201325
  25. Molecular characterization of Shaker, a Drosophila gene that encodes a potassium channel.
    Cell. 1987 Jul 31;50(3):405-13 PMID: 2440582
  26. Localization of antigenic determinants in whole Drosophila embryos.
    Dev Biol. 1983 Sep;99(1):261-4 PMID: 6194030
  27. A clonal analysis of the roles of somatic cells and germ line during oogenesis in Drosophila.
    Dev Biol. 1981 Nov;88(1):92-103 PMID: 7286449
  28. polyhomeotic: a gene required for the embryonic development of axon pathways in the central nervous system of Drosophila.
    Genes Dev. 1988 Jul;2(7):830-42 PMID: 2905316
  29. Phototactic and geotactic behavior of countercurrent defective mutants of Drosophila melanogaster.
    Behav Genet. 1977 Nov;7(6):447-55 PMID: 414732
  30. Fine structure analysis of a chromosome segment in Drosophila melanogaster. Analysis of x-ray-induced lethals.
    Mutat Res. 1968 Sep-Oct;6(2):235-44 PMID: 4890698
  31. Genetic Analysis of Three Dominant Female-Sterile Mutations Located on the X Chromosome of DROSOPHILA MELANOGASTER.
    Genetics. 1983 Oct;105(2):309-25 PMID: 17246162
  32. Mutational Analysis of the Region Surrounding the 93d Heat Shock Locus of DROSOPHILA MELANOGASTER.
    Genetics. 1984 Feb;106(2):249-65 PMID: 17246190
  33. Behavioral Mutants of DROSOPHILA MELANOGASTER. I. Isolation and Mapping of Mutations Which Decrease Flight Ability.
    Genetics. 1977 Sep;87(1):95-104 PMID: 17248760
  34. Requirements for zygotic gene activity during gastrulation in Drosophila melanogaster.
    Dev Biol. 1985 Oct;111(2):359-71 PMID: 3930314
  35. Genetic Characterization of the 87c Region of the Third Chromosome of DROSOPHILA MELANOGASTER.
    Genetics. 1979 Dec;93(4):917-34 PMID: 17248986
  36. Fine structure analysis of a chromosome segment in Drosophila melanogaster: analysis of ethyl methanesulphonate-induced lethals.
    Mutat Res. 1969 Jul-Aug;8(1):147-55 PMID: 4894421
  37. The question of the total gene number in Drosophila melanogaster.
    Genetics. 1986 Aug;113(4):869-95 PMID: 3091446
  38. Developmental genetics of the 2C-D region of the Drosophila X chromosome.
    Genetics. 1985 Sep;111(1):23-41 PMID: 3928431
  39. The distribution of randomly recovered X-ray-induced sex-linked genetic effects in Drosophila melanogaster.
    Genetics. 1981 Nov-Dec;99(3-4):461-80 PMID: 6806144
  40. The genetics of a small chromosome region of Drosophila melanogaster containing the structural gene for alcohol dehydrogenase. IV: scutoid, an antimorphic mutation.
    Genetics. 1982 Nov;102(3):401-20 PMID: 6816673
Article Info
Journal
Genetics
Abbr.
Genetics
ISSN
0016-6731
DOI
10.1093/genetics/121.2.313
Published
1989-02-00
Pages
313-31
Language
English
Region
United States
NLM ID
0374636
PMCID
PMC1203620
Subset
IM
External Links
PubMed source DOI: 10.1093/genetics/121.2.313 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2