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PMID: 24997521 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Lgr5 marks stem/progenitor cells in ovary and tubal epithelia.

Nature cell biology ·Vol. 16 ·No. 8 ·2014-08-00 ·Pages 745-57

Ng A, Tan S, Singh G, Rizk P, Swathi Y, Tan TZ, Huang RY, Leushacke M, Barker N

Abstract

The ovary surface epithelium (OSE) undergoes ovulatory tear and remodelling throughout life. Resident stem cells drive such tissue homeostasis in many adult epithelia, but their existence in the ovary has not been definitively proven. Lgr5 marks stem cells in multiple epithelia. Here we use reporter mice and single-molecule fluorescent in situ hybridization to document candidate Lgr5(+) stem cells in the mouse ovary and associated structures. Lgr5 is broadly expressed during ovary organogenesis, but becomes limited to the OSE in neonate life. In adults, Lgr5 expression is predominantly restricted to proliferative regions of the OSE and mesovarian-fimbria junctional epithelia. Using in vivo lineage tracing, we identify embryonic and neonate Lgr5(+) populations as stem/progenitor cells contributing to the development of the OSE cell lineage, as well as epithelia of the mesovarian ligament and oviduct/fimbria. Adult Lgr5(+) populations maintain OSE homeostasis and ovulatory regenerative repair in vivo. Thus, Lgr5 marks stem/progenitor cells of the ovary and tubal epithelia.

MeSH Terms
Adult Stem Cells/metabolism Animals Animals, Newborn Cell Lineage/genetics Embryonic Stem Cells/metabolism Epithelial Cells/cytology,metabolism Fallopian Tubes/cytology,growth & development,metabolism Female Gene Expression Genetic Markers Homeostasis/genetics Humans In Situ Hybridization, Fluorescence Mice Mice, Transgenic Models, Biological Ovary/cytology,growth & development,metabolism Receptors, G-Protein-Coupled/genetics Regeneration/genetics Transcriptome
Chemicals
Genetic Markers LGR5 protein, human Lgr5 protein, mouse Receptors, G-Protein-Coupled
Authors & Affiliations
9 authors, click to expand affiliations / ORCID
Ng Annie
A-STAR Institute of Medical Biology, 8A Biomedical Grove, 06-06 Immunos, 138648, Singapore.
Tan Shawna
A-STAR Institute of Medical Biology, 8A Biomedical Grove, 06-06 Immunos, 138648, Singapore.
Singh Gurmit
A-STAR Institute of Medical Biology, 8A Biomedical Grove, 06-06 Immunos, 138648, Singapore.
Rizk Pamela
A-STAR Institute of Medical Biology, 8A Biomedical Grove, 06-06 Immunos, 138648, Singapore.
Swathi Yada
A-STAR Institute of Medical Biology, 8A Biomedical Grove, 06-06 Immunos, 138648, Singapore.
Tan Tuan Zea
Cancer Science Institute of Singapore, National University of Singapore, 117599, Singapore.
Huang Ruby Yun-Ju
1] Cancer Science Institute of Singapore, National University of Singapore, 117599, Singapore [2] Department of Obstetrics &Gynaecology, National University Hospital, 119228, Singapore.
Leushacke Marc
A-STAR Institute of Medical Biology, 8A Biomedical Grove, 06-06 Immunos, 138648, Singapore.
Barker Nick
1] A-STAR Institute of Medical Biology, 8A Biomedical Grove, 06-06 Immunos, 138648, Singapore [2] Centre for Regenerative Medicine, 47 Little France Crescent, University of Edinburgh, EH16 4TJ, UK [3] Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 117596, Singapore.
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Article Info
Journal
Nature cell biology
Abbr.
Nat Cell Biol
ISSN
1476-4679
Published
2014-08-00
Epub
2014-00-06
Pages
745-57
Language
English
Region
England
NLM ID
100890575
Subset
IM
Databases
GEO
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