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PMID: 25005482 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Mobile DNA elements in the generation of diversity and complexity in the brain.

Nature reviews. Neuroscience ·Vol. 15 ·No. 8 ·2014-08-00 ·Pages 497-506

Erwin JA, Marchetto MC, Gage FH

Abstract

Mobile elements are DNA sequences that can change their position (retrotranspose) within the genome. Although its biological function is largely unappreciated, DNA derived from mobile elements comprises nearly half of the human genome. It has long been thought that neuronal genomes are invariable; however, recent studies have demonstrated that mobile elements actively retrotranspose during neurogenesis, thereby creating genomic diversity between neurons. In addition, mounting data demonstrate that mobile elements are misregulated in certain neurological disorders, including Rett syndrome and schizophrenia.

MeSH Terms
Brain/physiology DNA Transposable Elements Genome, Human Humans Neurons/physiology Retroelements Rett Syndrome/genetics Schizophrenia/genetics
Chemicals
DNA Transposable Elements Retroelements
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Erwin Jennifer A
Salk Institute for Biological Studies, Laboratory of Genetics, 10010 North Torrey Pines Road, La Jolla, California 92037, USA.
Marchetto Maria C
Salk Institute for Biological Studies, Laboratory of Genetics, 10010 North Torrey Pines Road, La Jolla, California 92037, USA.
Gage Fred H
Salk Institute for Biological Studies, Laboratory of Genetics, 10010 North Torrey Pines Road, La Jolla, California 92037, USA.
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Article Info
Journal
Nature reviews. Neuroscience
Abbr.
Nat Rev Neurosci
ISSN
1471-0048
DOI
10.1038/nrn3730
Published
2014-08-00
Epub
2014-00-09
Pages
497-506
Language
English
Region
England
NLM ID
100962781
PMCID
PMC4443810
Subset
IM
Grants
NIMH NIH HHS · R01 MH095741 · United States
NIMH NIH HHS · TR01 MH095741 · United States
External Links
PubMed source DOI: 10.1038/nrn3730 PMC Full Text View journal details
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