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PMID: 2501443 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Functional immunoglobulin light chain genes are replaced by ongoing rearrangements of germline V kappa genes to downstream J kappa segment in a murine B cell line.

The Journal of experimental medicine ·Vol. 170 ·No. 1 ·1989-07-01 ·Pages 1-13

Levy S, Campbell MJ, Levy R

Abstract

A murine B cell lymphoma (38C13) was subjected to immunoselection with mAbs directed against the idiotypic determinants of its cell surface Ig. Variants emerged with altered Ig receptors containing identical heavy chains but different light chains. The functional light chain genes in these variants were composed of V kappa segments drawn from the V kappa Ox-1 family, which had replaced the V kappa gene expressed by the parental tumor by rearranging to downstream J kappa segments. Rearrangement at the kappa locus continued to occur spontaneously, giving rise to secondary and tertiary variants at a rate of 1.9 x 10(-4) per cell per generation. Variants were isolated that had ceased production of surface Ig but went on to rearrange again and to become surface Ig+. The Ig- state may be an intermediate step providing a stimulus for continued rearrangement. This process provides an additional mechanism for generating diversity within B cell clones and expands the use of the available repertoire of Ig genes.

MeSH Terms
Animals B-Lymphocytes/immunology Base Sequence Cell Line Gene Rearrangement, B-Lymphocyte, Light Chain Genes, Immunoglobulin Immunoglobulin Idiotypes/genetics Immunoglobulin Joining Region/genetics Immunoglobulin Light Chains/genetics Immunoglobulin Variable Region/genetics Mice Molecular Sequence Data Transcription, Genetic
Chemicals
Immunoglobulin Idiotypes Immunoglobulin Joining Region Immunoglobulin Light Chains Immunoglobulin Variable Region
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Levy S
Department of Medicine, Stanford University School of Medicine, California 94305.
Campbell M J
Levy R
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34 references, click to expand
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
Published
1989-07-01
Pages
1-13
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2189373
Subset
IM
Grants
NIAID NIH HHS · AI-07290 · United States
NCI NIH HHS · CA-33399 · United States
NCI NIH HHS · CA-34233 · United States
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