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PMID: 2502434 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

The multicatalytic proteinase (prosome) is ubiquitous from eukaryotes to archaebacteria.

FEBS letters ·Vol. 251 ·No. 1-2 ·1989-07-17 ·Pages 125-31

Dahlmann B, Kopp F, Kuehn L, Niedel B, Pfeifer G, Hegerl R, Baumeister W

Abstract

From the thermoacidophilic archaebacterium, Thermoplasma acidophilum, a proteolytically active particle has been isolated which is almost identical in size and shape with the multicatalytic proteinase (prosome) from rat. This result indicates that prosomes have been developed early in evolution and that they possibly serve functions common to all living cells.

MeSH Terms

Animals Archaea/enzymology Bacteria/enzymology Biological Evolution Calcium Chloride/pharmacology Chromatography Cysteine Endopeptidases/isolation & purification,metabolism Electrophoresis, Polyacrylamide Gel Macromolecular Substances Microscopy, Electron Molecular Weight Multienzyme Complexes/isolation & purification,metabolism Muscles/enzymology Peptide Fragments Proteasome Endopeptidase Complex Rats Substrate Specificity

Chemicals

Macromolecular Substances Multienzyme Complexes Peptide Fragments Cysteine Endopeptidases Proteasome Endopeptidase Complex Calcium Chloride

Authors & Affiliations

7 authors, click to expand affiliations / ORCID

Dahlmann B

Diabetes Forschungsinstitut, Auf'm Hennekamp, Düsseldorf, FRG.

Kopp F

Kuehn L

Niedel B

Pfeifer G

Hegerl R

Baumeister W

Article Info

Journal

FEBS letters

Abbr.

FEBS Lett

ISSN

0014-5793

DOI

10.1016/0014-5793(89)81441-3

Published

1989-07-17

Pages

125-31

Language

English

Region

England

NLM ID

0155157

Subset

External Links

PubMed source DOI: 10.1016/0014-5793(89)81441-3 View journal details

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The multicatalytic proteinase (prosome) is ubiquitous from eukaryotes to archaebacteria.

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