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PMID: 2503712 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Regulation of tissue factor gene expression in the monocyte procoagulant response to endotoxin.

Molecular and cellular biology ·Vol. 9 ·No. 6 ·1989-06-00 ·Pages 2752-5

Gregory SA, Morrissey JH, Edgington TS

Abstract

Tissue factor is the cellular receptor and cofactor for plasma factor VIIa which initiates the coagulation protease cascade on cell surfaces. Although normally absent from all intravascular cell types, tissue factor can be induced to appear on circulating monocytes and vascular endothelial cells by specific inflammatory or immunological mediators. In this study, we have examined the regulation of endotoxin-induced tissue factor gene expression in peripheral blood monocytes.

MeSH Terms
Blotting, Northern Cells, Cultured Cycloheximide/pharmacology DNA/genetics DNA Probes Gene Expression Regulation/drug effects Humans Interferon-gamma/pharmacology Interleukin-1/biosynthesis Interleukin-3/pharmacology Lipopolysaccharides/pharmacology Monocytes/metabolism RNA, Messenger/genetics Recombinant Proteins Thromboplastin/genetics Tumor Necrosis Factor-alpha/biosynthesis,genetics
Chemicals
DNA Probes Interleukin-1 Interleukin-3 Lipopolysaccharides RNA, Messenger Recombinant Proteins Tumor Necrosis Factor-alpha Interferon-gamma DNA Thromboplastin Cycloheximide
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Gregory S A
Department of Immunology, Research Institute of Scripps Clinic, La Jolla, California 92037.
Morrissey J H
Edgington T S
References (28)
28 references, click to expand
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Article Info
Journal
Molecular and cellular biology
Abbr.
Mol Cell Biol
ISSN
0270-7306
DOI
10.1128/mcb.9.6.2752-2755.1989
Published
1989-06-00
Pages
2752-5
Language
English
Region
United States
NLM ID
8109087
PMCID
PMC362351
Subset
IM
Grants
NHLBI NIH HHS · P01 HL16411 · United States
External Links
PubMed source DOI: 10.1128/mcb.9.6.2752-2755.1989 PMC Full Text View journal details
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