Abstract
The Cox proportional hazards model is frequently used in medical statistics. The standard methods for fitting this model rely on the assumption of independent censoring. Although this is sometimes plausible, we often wish to explore how robust our inferences are as this untestable assumption is relaxed. We describe how this can be carried out in a way that makes the assumptions accessible to all those involved in a research project. Estimation proceeds via multiple imputation, where censored failure times are imputed under user-specified departures from independent censoring. A novel aspect of our method is the use of bootstrapping to generate proper imputations from the Cox model. We illustrate our approach using data from an HIV-prevention trial and discuss how it can be readily adapted and applied in other settings.
Keywords
Schoenfeld residuals
bootstrapping
informative censoring
multiple imputation
sensitivity analysis
survival analysis
MeSH Terms
Acyclovir
Adolescent
Adult
Antiviral Agents
Bias
Biometry/methods
Computer Simulation
Female
HIV Infections/prevention & control
Herpes Genitalis/drug therapy
Herpesvirus 2, Human
Humans
Monte Carlo Method
Proportional Hazards Models
Randomized Controlled Trials as Topic
Regression Analysis
Tanzania
Young Adult
Chemicals
Antiviral Agents
Acyclovir
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Jackson Dan
MRC Biostatistics Unit, Institute of Public Health, Forvie Site, Robinson Way, Cambridge, CB2 0SR, U.K.
White Ian R
Seaman Shaun
Evans Hannah
Baisley Kathy
Carpenter James
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