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PMID: 25071162 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Fibroblast heterogeneity in the cancer wound.

The Journal of experimental medicine ·Vol. 211 ·No. 8 ·2014-07-28 ·Pages 1503-23

Öhlund D, Elyada E, Tuveson D

Abstract

Fibroblasts regulate the structure and function of healthy tissues, participate transiently in tissue repair after acute inflammation, and assume an aberrant stimulatory role during chronic inflammatory states including cancer. Such cancer-associated fibroblasts (CAFs) modulate the tumor microenvironment and influence the behavior of neoplastic cells in either a tumor-promoting or tumor-inhibiting manner. These pleiotropic functions highlight the inherent plasticity of fibroblasts and may provide new avenues to understand and therapeutically intervene in malignancies. We discuss the emerging themes of CAF biology in the context of tumorigenesis and therapy.

MeSH Terms
Carcinogenesis/pathology Extracellular Matrix/metabolism Fibroblasts/pathology Humans Neoplasms/immunology,metabolism,pathology,therapy Neoplastic Stem Cells/metabolism,pathology Tumor Microenvironment
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Öhlund Daniel
D. Öhlund, E. Elyada, and D. Tuveson are at the Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724.
Elyada Ela
D. Öhlund, E. Elyada, and D. Tuveson are at the Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724.
Tuveson David
D. Öhlund, E. Elyada, and D. Tuveson are at the Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724 [email protected].
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
1540-9538
DOI
10.1084/jem.20140692
Email
[email protected]
Published
2014-07-28
Pages
1503-23
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC4113948
Subset
IM
Grants
NCI NIH HHS · 5P50CA101955-07 · United States
NCI NIH HHS · 1U10CA180944-01 · United States
NCI NIH HHS · P50 CA101955 · United States
NCI NIH HHS · 5U01CA168409-3 · United States
NCI NIH HHS · 5P30CA45508-26 · United States
NCI NIH HHS · U10 CA180944 · United States
NCI NIH HHS · P30 CA045508 · United States
NCI NIH HHS · U01 CA168409 · United States
External Links
PubMed source DOI: 10.1084/jem.20140692 PMC Full Text View journal details
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