Pancreatic islet-specific T-cell clones from nonobese diabetic mice.
We have produced a panel of islet-specific T-cell clones from nonobese diabetic (NOD) mice. These clones proliferate and make interleukin 2 in an antigen-specific manner in response to NOD antigen-presenting cells and islet cells. Most of the clones respond to islet-cell antigen from different mouse strains but only in the presence of antigen-presenting cells bearing the class II major histocompatibility complex of the NOD mouse. In vivo, the clones mediate the destruction of islet, but not pituitary, grafts. Furthermore, pancreatic sections from a disease transfer experiment with one of the clones showed a pronounced cellular infiltration and degranulation of islets in nondiabetic (CBA x NOD)F1 recipients.
16 references, click to expand
-
Continuous, clonal, insulin- and somatostatin-secreting cell lines established from a transplantable rat islet cell tumor.Proc Natl Acad Sci U S A. 1980 Jun;77(6):3519-23 PMID: 6106192
-
Beta-cell lines derived from transgenic mice expressing a hybrid insulin gene-oncogene.Proc Natl Acad Sci U S A. 1988 Dec;85(23):9037-41 PMID: 2848253
-
High frequency and nonrandom distribution of alloreactivity in T cell clones selected for recognition of foreign antigen in association with self class II molecules.J Immunol. 1986 Jan;136(2):389-95 PMID: 2416806
-
Transfer of autoimmune diabetes mellitus with splenocytes from nonobese diabetic (NOD) mice.Diabetes. 1986 Aug;35(8):855-60 PMID: 3525284
-
Prevention of diabetes in BioBreeding/Worcester rats with monoclonal antibodies that recognize T lymphocytes or natural killer cells.J Exp Med. 1986 Oct 1;164(4):1145-59 PMID: 3531381
-
Autoimmune diabetes in NOD mouse is L3T4 T-lymphocyte dependent.Diabetes. 1987 Apr;36(4):535-8 PMID: 3102301
-
Preventive effect of monoclonal anti-L3T4 antibody on development of diabetes in NOD mice.Diabetes. 1987 Apr;36(4):539-41 PMID: 3102302
-
The first external domain of the nonobese diabetic mouse class II I-A beta chain is unique.Proc Natl Acad Sci U S A. 1987 Apr;84(8):2435-9 PMID: 2882518
-
Treatment with anti-T-lymphocyte antibodies prevents induction of insulitis in mice given multiple doses of streptozocin.Diabetes. 1987 Jul;36(7):796-801 PMID: 3556279
-
Syngeneic transfer of autoimmune diabetes from diabetic NOD mice to healthy neonates. Requirement for both L3T4+ and Lyt-2+ T cells.J Exp Med. 1987 Oct 1;166(4):823-32 PMID: 3309126
-
Both the Lyt-2+ and L3T4+ T cell subsets are required for the transfer of diabetes in nonobese diabetic mice.J Immunol. 1988 Jan 1;140(1):52-8 PMID: 3275717
-
Immunotherapy of the nonobese diabetic mouse: treatment with an antibody to T-helper lymphocytes.Science. 1988 Apr 29;240(4852):659-62 PMID: 2966437
-
Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention.Cell. 1988 Jul 15;54(2):263-73 PMID: 2455603
-
NOD marrow stem cells adoptively transfer diabetes to resistant (NOD x NON)F1 mice.Diabetes. 1988 Feb;37(2):252-5 PMID: 3134263
-
T-lymphocyte clone specific for pancreatic islet antigen.Diabetes. 1988 Oct;37(10):1444-8 PMID: 2458291
-
Adoptive transfer of autoimmune diabetes mellitus in biobreeding/Worcester (BB/W) inbred and hybrid rats.J Immunol. 1985 Mar;134(3):1583-7 PMID: 3968427
Contact
No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong
Qilu Normal University · Genelibs Bioinformatics Lab
750 Shunhua Rd, Jinan
2F, Bldg F, University Science Park
Tel: 0531-88819269
WeChat Official Account
Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.
Business Email
E-mail: [email protected]
Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2
