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PMID: 2511176 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

bcl-2 gene rearrangement analysis in Japanese B cell lymphoma; novel bcl-2 recombination with immunoglobulin kappa chain gene.

Japanese journal of cancer research : Gann ·Vol. 80 ·No. 8 ·1989-08-00 ·Pages 711-5

Osada H, Seto M, Ueda R, Emi N, Takagi N, Obata Y, Suchi T, Takahashi T

Abstract

The rearrangement of bcl-2 gene was studied in 56 Japanese B cell lymphoma cases to investigate the contribution of bcl-2 gene to lymphomagenesis in Japan. Ten out of 56 cases showed bcl-2 gene rearrangement; it was detected in only 5 out of 16 follicular lymphoma cases (31%) and in 5 out of 40 diffuse B cell lymphoma cases (13%). The incidence of bcl-2 gene involvement in Japanese follicular lymphomas was lower than those reported in the United States. This might contribute to the lower incidence of follicular lymphoma cases in Japan. Novel recombination between bcl-2 and Ig kappa genes at the 5' region of bcl-2 and J kappa 4 segment was observed in one follicular lymphoma case, suggesting that bcl-2 gene is transcriptionally activated by Ig kappa enhancer. It was also suggested that this case had originated from a more differentiated B cell than most follicular lymphomas with bcl-2-Ig H recombination.

MeSH Terms
B-Lymphocytes/immunology Base Sequence Blotting, Southern Gene Rearrangement Genes, Immunoglobulin Humans Immunoglobulin kappa-Chains/genetics Japan Lymphoma/genetics,immunology Molecular Sequence Data Proto-Oncogene Proteins/genetics Proto-Oncogene Proteins c-bcl-2 Proto-Oncogenes/genetics Recombination, Genetic Restriction Mapping
Chemicals
Immunoglobulin kappa-Chains Proto-Oncogene Proteins Proto-Oncogene Proteins c-bcl-2
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Osada H
Laboratory of Immunology, Aichi Cancer Center, Nagoya.
Seto M
Ueda R
Emi N
Takagi N
Obata Y
Suchi T
Takahashi T
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Article Info
Journal
Japanese journal of cancer research : Gann
Abbr.
Jpn J Cancer Res
ISSN
0910-5050
DOI
10.1111/j.1349-7006.1989.tb01702.x
Published
1989-08-00
Pages
711-5
Language
English
Region
Japan
NLM ID
8509412
PMCID
PMC5917842
Subset
IM
External Links
PubMed source DOI: 10.1111/j.1349-7006.1989.tb01702.x PMC Full Text
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