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PMID: 25117708 Published · ppublish English Journal Article Comment

When deletions gain functions: commandeering epigenetic mechanisms.

Cancer cell ·Vol. 26 ·No. 2 ·2014-08-11 ·Pages 160-1

Chen J, Weiss WA

Abstract

Recurrent chromosomal deletions in cancer are typically thought to harbor tumor suppressors. In a recent publication in Nature, Northcott and colleagues identify a novel region of structural variation in medulloblastoma that leads to oncogenic activation of GFI1B and GFI1 by repositioning these genes next to super-enhancers.

MeSH Terms
Animals DNA-Binding Proteins/genetics Enhancer Elements, Genetic/genetics Genomic Structural Variation/genetics Humans Medulloblastoma/genetics Oncogenes/genetics Proto-Oncogene Proteins/genetics Repressor Proteins/genetics Transcription Factors/genetics
Chemicals
DNA-Binding Proteins Proto-Oncogene Proteins Repressor Proteins Transcription Factors
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Chen Justin
Departments of Neurology, Pediatrics, Neurosurgery, and Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA.
Weiss William A
Departments of Neurology, Pediatrics, Neurosurgery, and Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address: [email protected].
References (10)
10 references, click to expand
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Article Info
Journal
Cancer cell
Abbr.
Cancer Cell
ISSN
1878-3686
DOI
10.1016/j.ccr.2014.07.021
Email
[email protected]
Published
2014-08-11
Pages
160-1
Language
English
Region
United States
NLM ID
101130617
PMCID
PMC4134099
Subset
IM
Grants
NCI NIH HHS · U54 CA163155 · United States
NCI NIH HHS · R01 CA102321 · United States
NCI NIH HHS · U01 CA176287 · United States
NCI NIH HHS · P01 CA081403 · United States
NCI NIH HHS · R01 CA159859 · United States
NCI NIH HHS · P30 CA082103 · United States
NCI NIH HHS · R01 CA148699 · United States
NCI NIH HHS · R33 CA183692 · United States
Corrections
CommentOn
PMID: 25043047
External Links
PubMed source DOI: 10.1016/j.ccr.2014.07.021 PMC Full Text View journal details
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