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PMID: 2519621 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Retinoic acid induces transforming growth factor-beta 2 in cultured keratinocytes and mouse epidermis.

Cell regulation ·Vol. 1 ·No. 1 ·1989-11-00 ·Pages 87-97

Glick AB, Flanders KC, Danielpour D, Yuspa SH, Sporn MB

Abstract

We have studied the functional interaction between retinoic acid and transforming growth factor-beta (TGF-beta), using the mouse epidermis as a model system. Treatment with retinoic acid increases expression of TGF-beta 2 in cultured keratinocytes in vitro, as well as in the epidermis in vivo. This TGF-beta 2 is secreted in a biologically active form that can bind to surface receptors, in contrast to most other conditions in which TGF-beta is secreted in a latent form. Specific antibodies to TGF-beta 2 partially reverse the ability of retinoic acid to inhibit DNA synthesis in cultured keratinocytes. The regulation of TGF-beta 2 expression by retinoic acid may have important physiological and pharmacological roles in the maintenance of epidermal homeostasis.

MeSH Terms
Animals Cells, Cultured DNA/biosynthesis Female Keratinocytes/drug effects,metabolism Mice Mice, Inbred BALB C Skin/drug effects,metabolism Transcription, Genetic/drug effects Transforming Growth Factor beta/biosynthesis,genetics,metabolism Tretinoin/pharmacology
Chemicals
Transforming Growth Factor beta Tretinoin DNA
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Glick A B
Laboratory of Chemoprevention, National Cancer Institute, Bethesda, Maryland 20892.
Flanders K C
Danielpour D
Yuspa S H
Sporn M B
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Article Info
Journal
Cell regulation
Abbr.
Cell Regul
ISSN
1044-2030
DOI
10.1091/mbc.1.1.87
Published
1989-11-00
Pages
87-97
Language
English
Region
United States
NLM ID
9005331
PMCID
PMC361428
Subset
IM
External Links
PubMed source DOI: 10.1091/mbc.1.1.87 PMC Full Text
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