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PMID: 25209798 Published · ppublish English

Gibbon genome and the fast karyotype evolution of small apes.

Nature ·Vol. 513 ·No. 7517 ·2014-09-26

Carbone Lucia, Harris R Alan, Gnerre Sante, Veeramah Krishna R, Lorente-Galdos Belen, Huddleston John, Meyer Thomas J, Herrero Javier, Roos Christian, Aken Bronwen, Anaclerio Fabio, Archidiacono Nicoletta, Baker Carl, Barrell Daniel, Batzer Mark A, Beal Kathryn, Blancher Antoine, Bohrson Craig L, Brameier Markus, Campbell Michael S, Capozzi Oronzo, Casola Claudio, Chiatante Giorgia, Cree Andrew, Damert Annette, de Jong Pieter J, Dumas Laura, Fernandez-Callejo Marcos, Flicek Paul, Fuchs Nina V, Gut Ivo, Gut Marta, Hahn Matthew W, Hernandez-Rodriguez Jessica, Hillier LaDeana W, Hubley Robert, Ianc Bianca, Izsvák Zsuzsanna, Jablonski Nina G, Johnstone Laurel M, Karimpour-Fard Anis, Konkel Miriam K, Kostka Dennis, Lazar Nathan H, Lee Sandra L, Lewis Lora R, Liu Yue, Locke Devin P, Mallick Swapan, Mendez Fernando L, Muffato Matthieu, Nazareth Lynne V, Nevonen Kimberly A, O'Bleness Majesta, Ochis Cornelia, Odom Duncan T, Pollard Katherine S, Quilez Javier, Reich David, Rocchi Mariano, Schumann Gerald G, Searle Stephen, Sikela James M, Skollar Gabriella, Smit Arian, Sonmez Kemal, ten Hallers Boudewijn, Terhune Elizabeth, Thomas Gregg W C, Ullmer Brygg, Ventura Mario, Walker Jerilyn A, Wall Jeffrey D, Walter Lutz, Ward Michelle C, Wheelan Sarah J, Whelan Christopher W, White Simon, Wilhelm Larry J, Woerner August E, Yandell Mark, Zhu Baoli, Hammer Michael F, Marques-Bonet Tomas, Eichler Evan E, Fulton Lucinda, Fronick Catrina, Muzny Donna M, Warren Wesley C, Worley Kim C, Rogers Jeffrey, Wilson Richard K, Gibbs Richard A

Abstract

Gibbons are small arboreal apes that display an accelerated rate of evolutionary chromosomal rearrangement and occupy a key node in the primate phylogeny between Old World monkeys and great apes. Here we present the assembly and analysis of a northern white-cheeked gibbon (Nomascus leucogenys) genome. We describe the propensity for a gibbon-specific retrotransposon (LAVA) to insert into chromosome segregation genes and alter transcription by providing a premature termination site, suggesting a possible molecular mechanism for the genome plasticity of the gibbon lineage. We further show that the gibbon genera (Nomascus, Hylobates, Hoolock and Symphalangus) experienced a near-instantaneous radiation ∼5 million years ago, coincident with major geographical changes in southeast Asia that caused cycles of habitat compression and expansion. Finally, we identify signatures of positive selection in genes important for forelimb development (TBX5) and connective tissues (COL1A1) that may have been involved in the adaptation of gibbons to their arboreal habitat.

Article Info
Journal
Nature
Abbr.
Nature
Published
2014-09-26
Indexed
2014-09-11
Updated
2016-11-22
Language
English
Country/Region
England
NLM ID
0410462
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