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PMID: 2527866 Published · ppublish English Journal Article

Functional immunoregulatory T-cell abnormalities in cystic fibrosis patients.

Journal of clinical immunology ·Vol. 9 ·No. 4 ·1989-07-00 ·Pages 287-95

Lahat N, Rivlin J, Iancu TC

Abstract

The role of B cells and regulatory T cells in the reduced in vitro IgG synthesis of cystic fibrosis (CF) patients was studied. Intact proportion, proliferation, and differentiation of B cells and reduced suppressor and helper T-cell function were found. To explore the T-cell defects further, CF sera or supernatant derived from Pseudomonas aeruginosa cultures (PA supernatant) was added to the relevant T helper- and suppressor-cell assays. Both CF sera derived from PA-positive patients and PA supernatant interfered with the appearance of interleukin 2 (IL-2) receptors and with the functional enhancement caused by exogenously added IL-2. PA-negative CF patients, however, also had functional T-cell defects and inhibitory sera, but these sera did not affect IL-2 pathways. Thus different serum factors and intrinsic T-cell defects in CF patients are suggested.

MeSH Terms
Adolescent Adult Antibody-Producing Cells/metabolism Antigens, Surface/analysis B-Lymphocytes/physiology Child Child, Preschool Concanavalin A/pharmacology Cystic Fibrosis/immunology Female Humans Immunoglobulin G/metabolism In Vitro Techniques Infant Interleukin-2/pharmacology Interleukins/pharmacology Lymphocyte Activation Male Phenotype Pseudomonas aeruginosa/immunology T-Lymphocytes/physiology T-Lymphocytes, Regulatory/physiology
Chemicals
Antigens, Surface Immunoglobulin G Interleukin-2 Interleukins Concanavalin A
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Lahat N
Immunology Unit, Carmel Hospital, Haifa, Israel.
Rivlin J
Iancu T C
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34 references, click to expand
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Article Info
Journal
Journal of clinical immunology
Abbr.
J Clin Immunol
ISSN
0271-9142
DOI
10.1007/BF00918660
Published
1989-07-00
Pages
287-95
Language
English
Region
Netherlands
NLM ID
8102137
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00918660 View journal details
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