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PMID: 25341012 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Regulation of tumor metastasis by myeloid-derived suppressor cells.

Annual review of medicine ·Vol. 66 ·2015-00-00 ·Pages 97-110

Condamine T, Ramachandran I, Youn JI, Gabrilovich DI

Abstract

Accumulation of pathologically activated immature myeloid cells with potent immune-suppressive activity is one of the major immunological hallmarks of cancer. In recent years, it became clear that in addition to their immune-suppressive activity, myeloid-derived suppressor cells (MDSCs) influence tumor progression in a variety of ways. They are directly implicated in the promotion of tumor metastases by participating in the formation of premetastatic niches, promoting angiogenesis and tumor cell invasion. In this review, we discuss recent data describing various roles of MDSCs in the formation of tumor metastases.

Keywords
angiogenesis chemotherapy immune suppression tumor cell invasion
MeSH Terms
Humans Myeloid Cells/immunology Neoplasm Invasiveness/immunology Neoplasm Metastasis/immunology Neoplasms/immunology Neovascularization, Pathologic/immunology
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Condamine Thomas
The Wistar Institute, Philadelphia, Pennsylvania 19104; email: [email protected] , [email protected] , [email protected].
Ramachandran Indu
Youn Je-In
Gabrilovich Dmitry I
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Article Info
Journal
Annual review of medicine
Abbr.
Annu Rev Med
ISSN
1545-326X
DOI
10.1146/annurev-med-051013-052304
Email
[email protected]
[email protected]
[email protected]
Published
2015-00-00
Epub
2014-00-09
Pages
97-110
Language
English
Region
United States
NLM ID
2985151R
PMCID
PMC4324727
Subset
IM
Grants
NCI NIH HHS · R01 CA141438 · United States
NCI NIH HHS · R01 CA084488 · United States
NCI NIH HHS · CA 84488 · United States
NCI NIH HHS · R01 CA100062 · United States
NCI NIH HHS · P30 CA010815 · United States
NCI NIH HHS · CA 100062 · United States
External Links
PubMed source DOI: 10.1146/annurev-med-051013-052304 PMC Full Text View journal details
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