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PMID: 2536158 Published · ppublish English Journal Article

Is there a relationship between DNA sequences encoding peptide ligands and their receptors?

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 86 ·No. 1 ·1989-01-00 ·Pages 42-5

Goldstein A, Brutlag DL

Abstract

It has been suggested that the coding for a ligand and its receptor may have originated in inverse complementary strands of the same DNA. This would imply a deficiency of stop codons in the complementary strand of the ligand message sequence. We have sought evidence of such deficiencies by an analysis of the usage of selected codons in 23 human neuropeptide and hormone mRNA sequences. We have also searched directly for similarities between substance K or substance P and the substance K receptor. Although bovine proopiomelanocortin has an open reading frame for the full extent of the inverse complement of the coding region, this seems to be a unique case. The data as a whole do not support the hypothesis.

MeSH Terms
Amino Acid Sequence Animals Base Sequence Cattle Codon/genetics DNA/genetics Genes Hormones/genetics Humans Ligands Molecular Sequence Data Neurokinin A/genetics Neuropeptides/genetics Pro-Opiomelanocortin/genetics RNA, Messenger/genetics Receptors, Cell Surface/genetics Receptors, Neurokinin-2 Receptors, Neurotransmitter/genetics
Chemicals
Codon Hormones Ligands Neuropeptides RNA, Messenger Receptors, Cell Surface Receptors, Neurokinin-2 Receptors, Neurotransmitter Pro-Opiomelanocortin Neurokinin A DNA
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Goldstein A
Department of Pharmacology, Stanford University School of Medicine, CA 94305.
Brutlag D L
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.86.1.42
Published
1989-01-00
Pages
42-5
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC286399
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.86.1.42 PMC Full Text View journal details
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