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PMID: 2536900 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Designing CD4 immunoadhesins for AIDS therapy.

Nature ·Vol. 337 ·No. 6207 ·1989-02-09 ·Pages 525-31

Capon DJ, Chamow SM, Mordenti J, Marsters SA, Gregory T, Mitsuya H, Byrn RA, Lucas C, Wurm FM, Groopman JE

Abstract

A newly-constructed antibody-like molecule containing the gp120-binding domain of the receptor for human immunodeficiency virus blocks HIV-1 infection of T cells and monocytes. Its long plasma half-life, other antibody-like properties, and potential to block all HIV isolates, make it a good candidate for therapeutic use.

MeSH Terms
Acquired Immunodeficiency Syndrome/immunology,metabolism,therapy Adjuvants, Immunologic/chemical synthesis,metabolism,pharmacokinetics Animals Antigens, Surface/administration & dosage,chemical synthesis,immunology Binding Sites, Antibody Binding, Competitive Cell Adhesion Molecules Cell Line Drug Design HIV Envelope Protein gp120 Half-Life Humans Immunoglobulin G/administration & dosage,metabolism Mice Rabbits Receptors, Complement/analysis Receptors, Fc/analysis Receptors, HIV Receptors, Virus/administration & dosage,immunology Retroviridae Proteins/metabolism
Chemicals
Adjuvants, Immunologic Antigens, Surface Cell Adhesion Molecules HIV Envelope Protein gp120 Immunoglobulin G Receptors, Complement Receptors, Fc Receptors, HIV Receptors, Virus Retroviridae Proteins
Authors & Affiliations
10 authors, click to expand affiliations / ORCID
Capon D J
Department of Molecular Biology, Genentech, Inc., South San Francisco, California 94080.
Chamow S M
Mordenti J
Marsters S A
Gregory T
Mitsuya H
Byrn R A
Lucas C
Wurm F M
Groopman J E
Article Info
Journal
Nature
Abbr.
Nature
ISSN
0028-0836
Published
1989-02-09
Pages
525-31
Language
English
Region
England
NLM ID
0410462
Subset
IM
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