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PMID: 2539392 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Transforming growth factor-beta. Murine glomerular receptors and responses of isolated glomerular cells.

The Journal of clinical investigation ·Vol. 83 ·No. 4 ·1989-04-00 ·Pages 1160-7

MacKay K, Striker LJ, Stauffer JW, Doi T, Agodoa LY, Striker GE

Abstract

Proliferation of resident glomerular cells and the accumulation of mesangial matrix are histologic abnormalities which are observed in the course of many progressive glomerular diseases. We explored the potential regulatory effects of transforming growth factor-beta (TGF-beta) on these processes. We found that cultured mouse glomerular endothelial, mesangial, and epithelial cells as well as isolated intact rat glomeruli possess high-affinity receptors for TGF-beta. We also found that, although TGF-beta consistently inhibited the proliferation of glomerular endothelial and epithelial cells, it acted as a bifunctional regulator of mesangial cell proliferation. TGF-beta significantly increased the production of collagen and fibronectin by glomerular mesangial cells whereas only fibronectin production was augmented in glomerular epithelial cells. The presence of TGF-beta receptors on intact glomeruli and on each glomerular cell type and the demonstrated responsiveness of these cells to TGF-beta combine to suggest that potentially important interactions may occur between resident glomerular cells and TGF-beta in vivo.

MeSH Terms
Animals Cell Division/drug effects Cell Separation Collagen/biosynthesis Endothelium, Vascular/drug effects,metabolism Epithelium/drug effects,metabolism Female Fibronectins/biosynthesis Glomerular Mesangium/drug effects,metabolism Kidney Glomerulus/drug effects,metabolism Mice Rats Rats, Inbred Strains Receptors, Cell Surface/analysis Receptors, Transforming Growth Factor beta Transforming Growth Factors/metabolism,physiology
Chemicals
Fibronectins Receptors, Cell Surface Receptors, Transforming Growth Factor beta Transforming Growth Factors Collagen
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
MacKay K
Metabolic Disease Branch, National Institute of Diabetes and Digestive and Kidney Disease, Bethesda, Maryland 20892.
Striker L J
Stauffer J W
Doi T
Agodoa L Y
Striker G E
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Article Info
Journal
The Journal of clinical investigation
Abbr.
J Clin Invest
ISSN
0021-9738
DOI
10.1172/JCI113996
Published
1989-04-00
Pages
1160-7
Language
English
Region
United States
NLM ID
7802877
PMCID
PMC303802
Subset
IM
Grants
NIDDK NIH HHS · DK07843-02 · United States
External Links
PubMed source DOI: 10.1172/JCI113996 PMC Full Text View journal details
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