[Effect of camptothecin on the DNA-relaxing and DNA-cleavage activity of calf thymus topoisomerase I].

Vliianie kamptotetsina na DNK-relaksiruiushchuiu i DNK-rasshchepliaiushchuiu aktivnosti topoizomerazy I iz timusa telenka.

Molekuliarnaia biologiia ·Vol. 23 ·No. 2 ·1989-00-00 ·Pages 491-501

Bronshteĭn IB, Gromova II, Bukhman VL, Kafiani KA

Abstract

Nucleotide sequences that are cleaved by calf thymus type I topoisomerase have been determined using cloned human Ha-ras and p53 genes. Localization and relative frequency of single-strand cleavages within these sequences were observed to change in the presence of the cytotoxic alkaloid camptothecin.

MeSH Terms

Animals Base Sequence Camptothecin/pharmacology Cattle Cloning, Molecular DNA/metabolism DNA Topoisomerases, Type I/metabolism Electrophoresis, Agar Gel Genes, ras Humans Molecular Sequence Data Plasmids Thymus Gland/enzymology

Chemicals

DNA DNA Topoisomerases, Type I Camptothecin

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Bronshteĭn I B

Gromova I I

Bukhman V L

Kafiani K A

Article Info

Journal

Molekuliarnaia biologiia

Abbr.

Mol Biol (Mosk)

ISSN

0026-8984

Published

1989-00-00

Pages

491-501

Language

rus

Region

Russia (Federation)

NLM ID

0105454

Subset

External Links

PubMed source

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[Effect of camptothecin on the DNA-relaxing and DNA-cleavage activity of calf thymus topoisomerase I].

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