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PMID: 2552910 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

In vitro activities of daptomycin and other antimicrobial agents against vancomycin-resistant gram-positive bacteria.

Antimicrobial agents and chemotherapy ·Vol. 33 ·No. 8 ·1989-08-00 ·Pages 1383-4

de la Maza L, Ruoff KL, Ferraro MJ

Abstract

A comparative evaluation of daptomycin and eight other antimicrobial agents was performed by the agar dilution technique with 56 strains of vancomycin-resistant gram-positive bacteria, including Leuconostoc, Lactobacillus, and Pediococcus spp. Erythromycin, deptomycin, clindamycin, and gentamicin exhibited the greatest activities, whereas penicillin, ampicillin, and cefotaxime showed moderate activities. The organisms were all highly resistant to vancomycin and cefoxitin.

MeSH Terms
Anti-Bacterial Agents/pharmacology Daptomycin Drug Resistance, Microbial Gram-Positive Bacteria/drug effects Microbial Sensitivity Tests Peptides/pharmacology Vancomycin/pharmacology
Chemicals
Anti-Bacterial Agents Peptides Vancomycin Daptomycin
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
de la Maza L
Francis Blake Bacteriology Laboratories, Massachusetts General Hospital, Boston 02114.
Ruoff K L
Ferraro M J
References (10)
10 references, click to expand
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Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.33.8.1383
Published
1989-08-00
Pages
1383-4
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC172660
Subset
IM
External Links
PubMed source DOI: 10.1128/AAC.33.8.1383 PMC Full Text View journal details
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