Abstract
We have isolated a novel member of the tyrosine protein kinase family of cell surface receptors. This gene, designated trkB, is highly related to the human trk proto-oncogene. At the amino acid level, their respective products share a 57% homology in their extracellular regions including 9 of the 11 cysteines present in the trk proto-oncogene. This homology increases to 88% within their respective tyrosine kinase catalytic domains. Both trk and trkB are equally distantly related to the other members of this gene family of receptors. A biologically active cDNA clone of trkB can direct the synthesis of gp145trkB, a glycoprotein of 145 kd of which only 93 kd correspond to its polypeptide backbone. In adult mice, trkB is preferentially expressed in brain tissue, although significant levels of trkB RNA have also been observed in lung, muscle and ovaries. In addition, trkB transcripts can be detected in mid and late gestation embryos. The trkB locus exhibits a complex pattern of transcription. At least seven RNA species ranging in size from approximately 9 kb to 2 kb have been identified in brain. However, only a subset of these transcripts appears to be expressed in the other tissues. In situ hybridization analysis of 14 and 18 day old mouse embryos indicates that trkB transcripts are localized in the central (CNS) and peripheral (PNS) nervous systems, including brain, spinal cord, spinal and cranial ganglia, paravertebral trunk of the sympathetic nervous system and various innervation pathways. These results suggest that trkB may code for a novel cell surface receptor involved in neurogenesis.
MeSH Terms
Amino Acid Sequence
Animals
Base Sequence
DNA/isolation & purification
Genes
Humans
Mice
Molecular Sequence Data
Multigene Family
Neural Pathways/growth & development,metabolism
Nucleic Acid Hybridization
Oncogene Proteins/genetics
Protein-Tyrosine Kinases/metabolism
Proto-Oncogene Mas
Receptors, Cell Surface/biosynthesis,genetics,isolation & purification
Sequence Homology, Nucleic Acid
Transcription, Genetic
Chemicals
MAS1 protein, human
Oncogene Proteins
Proto-Oncogene Mas
Receptors, Cell Surface
oncogene protein trk
DNA
Protein-Tyrosine Kinases
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Klein R
Department of Molecular Biology, Squibb Institute for Medical Research, Princeton, NJ 08543.
Parada L F
Coulier F
Barbacid M
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