AIDS-associated Kaposi's sarcoma: a molecular model for its pathogenesis.

Cancer cells (Cold Spring Harbor, N.Y. : 1989) ·Vol. 1 ·No. 3 ·1989-11-00 ·Pages 93-6

Ensoli B, Salahuddin SZ, Gallo RC

Abstract

Kaposi's sarcoma is a mesenchymal tumor that is frequently observed in AIDS patients. Although the tumor is clearly associated with HIV-1 infection, little is known about the molecular events underlying its pathogenesis. Here we consider the potential roles of specific cytokines and the virally encoded tat product in inducing the tumor.

MeSH Terms

Acquired Immunodeficiency Syndrome/complications,genetics Gene Products, tat Growth Substances/genetics HIV-1/genetics Humans Models, Biological Sarcoma, Kaposi/etiology,genetics Trans-Activators tat Gene Products, Human Immunodeficiency Virus

Chemicals

Gene Products, tat Growth Substances Trans-Activators tat Gene Products, Human Immunodeficiency Virus

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Ensoli B

Laboratory of Tumor Cell Biology, National Cancer Institute, NIH, Bethesda, Maryland 20892.

Salahuddin S Z

Gallo R C

Article Info

Journal

Cancer cells (Cold Spring Harbor, N.Y. : 1989)

Abbr.

Cancer Cells

ISSN

1042-2196

Published

1989-11-00

Pages

93-6

Language

English

Region

United States

NLM ID

9000382

Subset

External Links

PubMed source

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AIDS-associated Kaposi's sarcoma: a molecular model for its pathogenesis.

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