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PMID: 2563508 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Predisposing locus for Alzheimer's disease on chromosome 21.

Lancet (London, England) ·Vol. 1 ·No. 8634 ·1989-02-18 ·Pages 352-5

Goate AM, Haynes AR, Owen MJ, Farrall M, James LA, Lai LY, Mullan MJ, Roques P, Rossor MN, Williamson R

Abstract

Linkage between Alzheimer's disease and markers on the long arm of chromosome 21 was investigated in six families affected by disease of early onset. Linkage was confirmed and the disease locus shown to be centromeric to the locus D21S1/S11 on the long arm of the chromosome. It is argued that the data are consistent with the notion that all patients with Alzheimer's disease of genetic aetiology have a predisposing locus on chromosome 21.

MeSH Terms

Adult Alzheimer Disease/genetics Blotting, Southern Chromosome Aberrations/genetics Chromosome Disorders Chromosome Mapping Chromosomes, Human, Pair 21 Female Genetic Linkage Humans Male Middle Aged Mutation Polymorphism, Restriction Fragment Length Recombination, Genetic

Authors & Affiliations

10 authors, click to expand affiliations / ORCID

Goate A M

Department of Biochemistry, St Mary's Hospital Medical School, London, England.

Haynes A R

Owen M J

Farrall M

James L A

Lai L Y

Mullan M J

Roques P

Rossor M N

Williamson R

Article Info

Journal

Lancet (London, England)

Abbr.

Lancet

ISSN

0140-6736

DOI

10.1016/s0140-6736(89)91725-x

Published

1989-02-18

Pages

352-5

Language

English

Region

England

NLM ID

2985213R

Subset

External Links

PubMed source DOI: 10.1016/s0140-6736(89)91725-x View journal details

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Predisposing locus for Alzheimer's disease on chromosome 21.

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