Prosomes discriminate between mRNA of adenovirus-infected and uninfected HeLa cells.

FEBS letters ·Vol. 246 ·No. 1-2 ·1989-03-27 ·Pages 131-6

Horsch A, Martins de Sa C, Dineva B, Spindler E, Schmid HP

Abstract

Prosomes are small cytoplasmic RNP complexes associated with repressed mRNA. In in vitro translation, they discriminate between the mRNA of adenovirus-infected HeLa cells and those of uninfected cells grown under normal conditions. Prosomes as well as their RNA constituents interact much more strongly with poly(A)+ mRNA of infected cells and inhibit their translation in vitro preferentially. A possible role of prosomes in the differential regulation of translation is discussed.

MeSH Terms

Adenoviridae/genetics,physiology Animals Cytoplasm/metabolism DNA, Viral/metabolism Electrophoresis, Polyacrylamide Gel Globins/genetics HeLa Cells Humans Molecular Weight Nucleic Acid Hybridization Poly A/metabolism Polyribosomes/analysis Protein Biosynthesis RNA, Messenger/metabolism RNA, Viral/metabolism Rabbits Ribonucleoproteins/metabolism

Chemicals

DNA, Viral RNA, Messenger RNA, Viral Ribonucleoproteins Poly A Globins

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Horsch A

Biologisches Institut, Universität Stuttgart, FRG.

Martins de Sa C

Dineva B

Spindler E

Schmid H P

Article Info

Journal

FEBS letters

Abbr.

FEBS Lett

ISSN

0014-5793

DOI

10.1016/0014-5793(89)80268-6

Published

1989-03-27

Pages

131-6

Language

English

Region

England

NLM ID

0155157

Subset

External Links

PubMed source DOI: 10.1016/0014-5793(89)80268-6 View journal details

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Prosomes discriminate between mRNA of adenovirus-infected and uninfected HeLa cells.

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