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PMID: 2565870 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

A new polymorphic marker very closely linked to DXS52 in the q28 region of the human X chromosome.

Human genetics ·Vol. 82 ·No. 1 ·1989-04-00 ·Pages 85-6

Vincent A, Kretz C, Oberlé I, Mandel JL

Abstract

We have isolated an X chromosome probe, St35.691 (DXS305), which detects two RFLPs with TaqI and PstI, whose combined heterozygosity is about 60%. This probe has been assigned to Xq28 by physical and genetic mapping and is very closely linked to DXS52, DXS15, and the coagulation factor VIII gene (F8C). The best estimate of the recombination fraction for the DXS52-DXS305 interval is 0.014, with a lod score of 50.1. Multipoint analysis places DXS305 on the same side of F8C as DXS52, but complete ordering of the three loci was not possible with our present data. This highly informative marker should be useful in the precise mapping of the many disease genes that have been assigned to the Xq28 band.

MeSH Terms

DNA Probes Genetic Linkage Humans Polymorphism, Genetic Polymorphism, Restriction Fragment Length Recombination, Genetic X Chromosome/ultrastructure

Chemicals

DNA Probes

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Vincent A

Laboratoire de Génétique Moléculaire des Eucaryotes du CNRS, Unité 184 de Biologie Moléculaire et de Génie Génétique de l'INSERM, Faculté de Médecine, Strasbourg, France.

Kretz C

Oberlé I

Mandel J L

References (8)

8 references, click to expand

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From hemophilia B to hemophilia A via the fragile X locus: genes and recombination in the distal region of the human X chromosome long arm.
Horiz Biochem Biophys. 1986;8:51-89 PMID: 2875934
Mapping of DNA markers close to the fragile site on the human X chromosome at Xq27.3.
Nucleic Acids Res. 1987 Mar 25;15(6):2639-51 PMID: 2882476
Toward a physical map of the Xq28 region in man: linking color vision, G6PD, and coagulation factor VIII genes to an X-Y homology region.
Genomics. 1989 May;4(4):460-71 PMID: 2501212
Physical mapping studies on the human X chromosome in the region Xq27-Xqter.
Genomics. 1987 Dec;1(4):297-306 PMID: 3482420
Multilocus linkage analysis in humans: detection of linkage and estimation of recombination.
Am J Hum Genet. 1985 May;37(3):482-98 PMID: 3859205
The gene for incontinentia pigmenti is assigned to Xq28.
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Article Info

Journal

Human genetics

Abbr.

Hum Genet

ISSN

0340-6717

DOI

10.1007/BF00288280

Published

1989-04-00

Pages

85-6

Language

English

Region

Germany

NLM ID

7613873

Subset

External Links

PubMed source DOI: 10.1007/BF00288280 View journal details

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A new polymorphic marker very closely linked to DXS52 in the q28 region of the human X chromosome.

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