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PMID: 2566595 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Bacteriophage association of streptococcal pyrogenic exotoxin type C.

Journal of bacteriology ·Vol. 171 ·No. 6 ·1989-06-00 ·Pages 3068-73

Goshorn SC, Schlievert PM

Abstract

A gene encoding streptococcal pyrogenic exotoxin type C (SPE C) was isolated from bacteriophage DNA derived from Streptococcus pyogenes CS112. The gene, designated speC2, was shown to reside near the phage attachment site of phage CS112. A restriction endonuclease map of the CS112 phage was generated, and the location and orientation of the speC2 gene were determined. Hybridization analyses of eight SPE C-producing strains revealed restriction fragment length polymorphism of the speC gene-containing DNA fragments and further showed that each speC was linked to a common CS112 phage-derived DNA fragment.

MeSH Terms
Bacterial Toxins/genetics Bacteriophages/genetics Cloning, Molecular DNA, Viral/genetics Exotoxins/genetics Genes Genes, Viral Immunodiffusion Nucleic Acid Hybridization Polymorphism, Restriction Fragment Length Restriction Mapping Streptococcus pyogenes/genetics
Chemicals
Bacterial Toxins DNA, Viral Exotoxins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Goshorn S C
Department of Microbiology, Medical School, University of Minnesota, Minneapolis 55455.
Schlievert P M
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Article Info
Journal
Journal of bacteriology
Abbr.
J Bacteriol
ISSN
0021-9193
DOI
10.1128/jb.171.6.3068-3073.1989
Published
1989-06-00
Pages
3068-73
Language
English
Region
United States
NLM ID
2985120R
PMCID
PMC210016
Subset
IM
Grants
NCI NIH HHS · 5T32 CA09138 · United States
NHLBI NIH HHS · HL36611 · United States
External Links
PubMed source DOI: 10.1128/jb.171.6.3068-3073.1989 PMC Full Text View journal details
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