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PMID: 2567894 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Inositol 1,4,5-trisphosphate phosphatase deficiency and malignant hyperpyrexia in swine.

Lancet (London, England) ·Vol. 2 ·No. 8655 ·1989-07-15 ·Pages 124-7

Foster PS, Gesini E, Claudianos C, Hopkinson KC, Denborough MA

Abstract

The sarcoplasmic reticulum from muscle of swine which are susceptible to malignant hyperpyrexia is deficient in inositol 1,4,5-trisphosphate phosphatase (InsP35-ase) activity, which leads to high intracellular concentrations of inositol 1,4,5-trisphosphate (InsP3) and of calcium ions. Halothane inhibits InsP35-ase and further increases myoplasmic InsP3 and calcium ion concentrations, and produces the clinical features of malignant hyperpyrexia.

MeSH Terms

Animals Calcium/analysis Halothane/pharmacology Inositol 1,4,5-Trisphosphate Inositol Phosphates/analysis Malignant Hyperthermia/enzymology Methods Muscle Contraction/drug effects Phosphoric Monoester Hydrolases/antagonists & inhibitors,deficiency Phosphorylation Sarcoplasmic Reticulum/enzymology Sugar Phosphates/analysis Swine

Chemicals

Inositol Phosphates Sugar Phosphates Inositol 1,4,5-Trisphosphate Phosphoric Monoester Hydrolases myo-inositol 1,4,5-triphosphate phosphatase Calcium Halothane

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Foster P S

Division of Biochemistry and Molecular Biology, John Curtin School of Medical Research, Australian National University, Canberra A.C.T.

Gesini E

Claudianos C

Hopkinson K C

Denborough M A

Article Info

Journal

Lancet (London, England)

Abbr.

Lancet

ISSN

0140-6736

DOI

10.1016/s0140-6736(89)90182-7

Published

1989-07-15

Pages

124-7

Language

English

Region

England

NLM ID

2985213R

Subset

External Links

PubMed source DOI: 10.1016/s0140-6736(89)90182-7 View journal details

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Inositol 1,4,5-trisphosphate phosphatase deficiency and malignant hyperpyrexia in swine.

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