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PMID: 2568346 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

In vitro adherence of type 1-fimbriated uropathogenic Escherichia coli to human ureteral mucosa.

Infection and immunity ·Vol. 57 ·No. 8 ·1989-08-00 ·Pages 2574-9

Fujita K, Yamamoto T, Yokota T, Kitagawa R

Abstract

Type 1-fimbriated Escherichia coli isolated from patients with urinary tract infections adhered in vitro to the epithelial cell surface of an excised human ureter. The bacteria also adhered to a mucous coating and to Formalin-fixed human ureteral mucosa. D-Mannose strongly inhibited such adherence. The bacteria in their nonfimbriated phase lacked the ability to adhere. We concluded that type 1 fimbriae play a role, at least in part, in upper urinary tract infections in humans.

MeSH Terms
Adult Bacterial Adhesion Carcinoma, Renal Cell/microbiology,ultrastructure Epithelium/microbiology,ultrastructure Escherichia coli/classification,physiology,ultrastructure Escherichia coli Infections/microbiology,pathology Female Fimbriae, Bacterial/physiology Humans Middle Aged Mucous Membrane/microbiology,ultrastructure Ureteral Diseases/microbiology,pathology
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Fujita K
Department of Urology, School of Medicine, Juntendo University, Tokyo, Japan.
Yamamoto T
Yokota T
Kitagawa R
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16 references, click to expand
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.57.8.2574-2579.1989
Published
1989-08-00
Pages
2574-9
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC313490
Subset
IM
Corrections
ErratumIn
-
External Links
PubMed source DOI: 10.1128/iai.57.8.2574-2579.1989 PMC Full Text View journal details
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