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PMID: 2573058 Published · ppublish English Comparative Study Journal Article

Drosophila NK-homeobox genes.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 86 ·No. 20 ·1989-10-00 ·Pages 7716-20

Kim Y, Nirenberg M

Abstract

Four Drosophila melanogaster homeobox genes were found by screening a genomic DNA library with oligodeoxynucleotides that correspond to a conserved amino acid sequence that is part of the putative of homeobox proteins that recognizes nucleotide sequences in DNA. The amino acid sequences of NK-2, NK-3, and NK-4 homeoboxes are more closely related to one another (59-66% homology) than they are to other Drosophila homeoboxes (28-54% homology), whereas the homeobox of NK-1 is most closely related, in order of decreasing homology, to muscle segment homeobox, zerknüllt-1, NK-3, and distal-less homeoboxes. Three of the genes, NK-1, NK-3, and NK-4, comprise a cluster of homeobox genes located in the 93E1-5 region of the right arm of the third chromosome, whereas the fourth homeobox gene, NK-2, is located in the 1C1-5 region of the X chromosome.

MeSH Terms
Amino Acid Sequence Animals Base Sequence Chromosome Mapping Cloning, Molecular DNA-Binding Proteins/genetics Drosophila melanogaster/genetics Genes Genes, Homeobox Genomic Library Molecular Sequence Data Oligonucleotide Probes Restriction Mapping Sequence Homology, Nucleic Acid
Chemicals
DNA-Binding Proteins Oligonucleotide Probes
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Kim Y
Laboratory of Biochemical Genetics, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892.
Nirenberg M
References (35)
35 references, click to expand
  1. The role of localization of bicoid RNA in organizing the anterior pattern of the Drosophila embryo.
    EMBO J. 1988 Jun;7(6):1749-56 PMID: 2901954
  2. Structure and expression of a family of Ultrabithorax mRNAs generated by alternative splicing and polyadenylation in Drosophila.
    Genes Dev. 1989 Feb;3(2):243-58 PMID: 2565858
  3. Evidence that the Abdominal-B r element function is conferred by a trans-regulatory homeoprotein.
    EMBO J. 1988 Oct;7(10):3223-31 PMID: 2903049
  4. Secondary structure determination for the Antennapedia homeodomain by nuclear magnetic resonance and evidence for a helix-turn-helix motif.
    EMBO J. 1988 Dec 20;7(13):4305-9 PMID: 2907480
  5. In vivo binding pattern of a trans-regulator of homoeotic genes in Drosophila melanogaster.
    Nature. 1989 Feb 2;337(6206):468-71 PMID: 2563569
  6. Sequence of a Drosophila segmentation gene: protein structure homology with DNA-binding proteins.
    Nature. 1984 Jul 5-11;310(5972):25-31 PMID: 6330566
  7. Homeo box gene expression in anterior and posterior regions of the Drosophila embryo.
    Proc Natl Acad Sci U S A. 1986 Jul;83(13):4809-13 PMID: 3014511
  8. Molecular structure and spatial expression of a homeobox gene from the labial region of the Antennapedia-complex.
    EMBO J. 1988 Aug;7(8):2569-78 PMID: 2461299
  9. Structural organization and sequence of the homeotic gene Antennapedia of Drosophila melanogaster.
    EMBO J. 1986 Apr;5(4):733-9 PMID: 10408949
  10. Base composition-independent hybridization in tetramethylammonium chloride: a method for oligonucleotide screening of highly complex gene libraries.
    Proc Natl Acad Sci U S A. 1985 Mar;82(6):1585-8 PMID: 3856838
  11. Structure of the segmentation gene paired and the Drosophila PRD gene set as part of a gene network.
    Cell. 1986 Dec 5;47(5):735-46 PMID: 2877746
  12. The POU domain: a large conserved region in the mammalian pit-1, oct-1, oct-2, and Caenorhabditis elegans unc-86 gene products.
    Genes Dev. 1988 Dec;2(12A):1513-6 PMID: 3215510
  13. Characterization and localization of the even-skipped protein of Drosophila.
    EMBO J. 1987 Mar;6(3):749-59 PMID: 2884106
  14. Zeste encodes a sequence-specific transcription factor that activates the Ultrabithorax promoter in vitro.
    Cell. 1988 Jun 3;53(5):713-22 PMID: 3131017
  15. The engrailed locus of Drosophila: structural analysis of an embryonic transcript.
    Cell. 1985 Jan;40(1):37-43 PMID: 3917855
  16. The isolation of structural genes from libraries of eucaryotic DNA.
    Cell. 1978 Oct;15(2):687-701 PMID: 719759
  17. Pattern formation in the developing eye of Drosophila melanogaster is regulated by the homoeo-box gene, rough.
    Nature. 1988 Jul 14;334(6178):151-4 PMID: 2898735
  18. Developmental and molecular analysis of Deformed; a homeotic gene controlling Drosophila head development.
    EMBO J. 1987 Mar;6(3):767-77 PMID: 16453752
  19. Determination of anteroposterior polarity in Drosophila.
    Science. 1987 Dec 18;238(4834):1675-81 PMID: 3686007
  20. Expression and function of the segmentation gene fushi tarazu during Drosophila neurogenesis.
    Science. 1988 Jan 8;239(4836):170-5 PMID: 2892267
  21. A novel, tissue-specific, Drosophila homeobox gene.
    EMBO J. 1988 Jul;7(7):2151-61 PMID: 2901348
  22. The segmentation and homeotic gene network in early Drosophila development.
    Cell. 1987 Dec 4;51(5):689-98 PMID: 2890437
  23. Segmentation and homeotic gene function in the developing nervous system of Drosophila.
    Trends Neurosci. 1988 Mar;11(3):101-6 PMID: 2465606
  24. DNA sequencing with chain-terminating inhibitors.
    Proc Natl Acad Sci U S A. 1977 Dec;74(12):5463-7 PMID: 271968
  25. Isolation and sequence-specific DNA binding of the Antennapedia homeodomain.
    EMBO J. 1988 Dec 20;7(13):4299-304 PMID: 2907479
  26. Distal-less encodes a homoeodomain protein required for limb development in Drosophila.
    Nature. 1989 Mar 30;338(6214):432-4 PMID: 2564639
  27. The invected gene of Drosophila: sequence analysis and expression studies reveal a close kinship to the engrailed gene.
    Genes Dev. 1987 Mar;1(1):19-28 PMID: 2892756
  28. Structure of transcripts from the homeotic Antennapedia gene of Drosophila melanogaster: two promoters control the major protein-coding region.
    Mol Cell Biol. 1986 Dec;6(12):4676-89 PMID: 2879223
  29. Isolation, structure, and expression of even-skipped: a second pair-rule gene of Drosophila containing a homeo box.
    Cell. 1986 Dec 5;47(5):721-34 PMID: 2877745
  30. Structure of two genes at the gooseberry locus related to the paired gene and their spatial expression during Drosophila embryogenesis.
    Genes Dev. 1987 Dec;1(10):1247-67 PMID: 3123319
  31. Molecular characterization of the zerknüllt region of the Antennapedia gene complex in Drosophila.
    Genes Dev. 1987 Dec;1(10):1268-79 PMID: 2892759
  32. The homeotic gene Sex Combs Reduced of Drosophila: gene structure and embryonic expression.
    EMBO J. 1989 Jan;8(1):219-27 PMID: 2565809
  33. Homeo boxes in the study of development.
    Science. 1987 Jun 5;236(4806):1245-52 PMID: 2884726
  34. rough, a Drosophila homeobox gene required in photoreceptors R2 and R5 for inductive interactions in the developing eye.
    Cell. 1988 Dec 2;55(5):771-84 PMID: 2903798
  35. Expression of the caudal gene in the germ line of Drosophila: formation of an RNA and protein gradient during early embryogenesis.
    Cell. 1987 Feb 13;48(3):465-78 PMID: 2433048
Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.86.20.7716
Published
1989-10-00
Pages
7716-20
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC298141
Subset
IM
Databases
GENBANK
M27289, M27290, M27291, M27292
External Links
PubMed source DOI: 10.1073/pnas.86.20.7716 PMC Full Text View journal details
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