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PMID: 25761876 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

COL11A1/(pro)collagen 11A1 expression is a remarkable biomarker of human invasive carcinoma-associated stromal cells and carcinoma progression.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine ·Vol. 36 ·No. 4 ·2015-04-00 ·Pages 2213-22

Vázquez-Villa F, García-Ocaña M, Galván JA, García-Martínez J, García-Pravia C, Menéndez-Rodríguez P, González-del Rey C, Barneo-Serra L, de Los Toyos JR

Abstract

The COL11A1 human gene codes for the α1 chain of procollagen 11A1 and mature collagen 11A1, an extracellular minor fibrillar collagen. Under regular conditions, this gene and its derived products are mainly expressed by chondrocytes and mesenchymal stem cells as well as osteoblasts. Normal epithelial cells and quiescent fibroblasts from diverse locations do not express them. Mesenchyme-derived tumors and related conditions, such as scleroderma and keloids, are positive for COL11A1/(pro)collagen 11A1 expression, as well as high-grade human gliomas/glioblastomas. This expression is almost absent in benign pathological processes such as breast hyperplasia, sclerosing adenosis, idiopathic pulmonary fibrosis, cirrhosis, pancreatitis, diverticulitis, and inflammatory bowel disease. By contrast, COL11A1/(pro)collagen 11A1 is highly expressed by activated stromal cells of the desmoplastic reaction of different human invasive carcinomas, and this expression is correlated with carcinoma aggressiveness and progression, and lymph node metastasis. COL11A1 upregulation has been shown to be associated to TGF-β1, Wnt, and Hh signaling pathways, which are especially active in cancer-associated stromal cells. At the front of invasive carcinomas, neoplastic epithelial cells, putatively undergoing epithelial-to-mesenchymal transition, and carcinoma-derived cells with highly metastatic capabilities, can express COL11A1. Thus, in established metastases, the expression of COL11A1/(pro)collagen 11A1 could rely on both the metastatic epithelial cells and/or the accompanying activated stromal cells. COL11A1/(pro)collagen 11A1 expression is a remarkable biomarker of human carcinoma-associated stromal cells and carcinoma progression.

MeSH Terms
Carcinogenesis Carcinoma/genetics,pathology Collagen Type XI/biosynthesis,genetics Gene Expression Regulation, Neoplastic Humans Neoplasm Invasiveness/genetics Neoplasms/genetics,pathology Transforming Growth Factor beta1/genetics
Chemicals
COL11A1 protein, human Collagen Type XI Transforming Growth Factor beta1
Authors & Affiliations
9 authors, click to expand affiliations / ORCID
Vázquez-Villa Fernando
Surgery Department, School of Medicine and Health Sciences, University of Oviedo, 33006, Oviedo, Spain.
García-Ocaña Marcos
Galván José A
García-Martínez Jorge
García-Pravia Carmen
Menéndez-Rodríguez Primitiva
González-del Rey Carmen
Barneo-Serra Luis
de Los Toyos Juan R
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Article Info
Journal
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
Abbr.
Tumour Biol
ISSN
1423-0380
DOI
10.1007/s13277-015-3295-4
Published
2015-04-00
Epub
2015-00-12
Pages
2213-22
Language
English
Region
Netherlands
NLM ID
8409922
Subset
IM
External Links
PubMed source DOI: 10.1007/s13277-015-3295-4
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